ArticleRespirology (Carlton, Vic.)2015
Inflammatory markers and mortality among US adults with obstructive lung function.
Article in Respirology (Carlton, Vic.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- C-reactive protein level predicts mortality in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2017Pooled it
- Decreased Lung Function and All-Cause Mortality in HIV-infected Individuals.Annals of the American Thoracic Society · 2018Trial
- Association of leukocyte count with death in people with HIV: A longitudinal study over 24 years.PloS one · 2026Article
- Accelerated biological aging mediates the association between inflammatory markers with Helicobacter pylori infection and mortality.Journal of translational medicine · 2025Article
- Are elevated plasma fibrinogen associated with lung function? An 8-year follow-up of the ELSA study.PloS one · 2021Article
- Observational
- Serum Human Epididymal Protein 4 is Associated with Depressive Symptoms in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2020Article
- Fibrinogen as a potential biomarker for clinical phenotype in patients with chronic obstructive pulmonary disease.Journal of thoracic disease · 2018Article
- Inflammatory status and lung function predict mortality in lung cancer screening participants.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
BACKGROUND AND
objectiveChronic obstructive pulmonary disease is characterized by an inflammatory state of uncertain significance. The objective of this study was to examine the association between elevated inflammatory marker count (white blood cell count, C-reactive protein and fibrinogen) on all-cause mortality in a national sample of US adults with obstructive lung function (OLF).
methodsData for 1144 adults aged 40-79 years in the National Health and Nutrition Examination Survey III Linked Mortality Study were analysed. Participants entered the study from 1988 to 1994, and mortality surveillance was conducted through 2006. White blood cell count and fibrinogen were dichotomized at their medians, and C-reactive protein was divided into >3 and ≤3 g/L. The number of elevated inflammatory markers was summed to create a score of 0-3.
resultsThe age-adjusted distribution of the number of elevated inflammatory markers differed significantly among participants with normal lung function, mild OLF, and moderate or worse OLF. Of the three dichotomized markers, only fibrinogen was significantly associated with mortality among adults with any OLF (maximally adjusted hazard ratio 1.49; 95% confidence interval (CI): 1.17-1.91). The maximally adjusted hazard ratios for having 1, 2 or 3 elevated markers were 1.17 (95% CI: 0.71-1.94), 1.44 (95% CI: 0.89-2.32) and 2.08 (95% CI: 1.29-3.37), respectively (P=0.003).
conclusionsAn index of elevated inflammatory markers predicted all-cause mortality among adults with OLF.
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