ArticleMolecular biology of the cell2015
Wash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Nuclear envelope budding: Getting large macromolecular complexes out of the nucleus.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Article
- Centralspindlin proteins Pavarotti and Tumbleweed along with WASH regulate nuclear envelope budding.The Journal of cell biology · 2023Article
- Scar/WAVE has Rac GTPase-independent functions during cell wound repair.Scientific reports · 2023Article
- Coordinated efforts of different actin filament populations are needed for optimal cell wound repair.Molecular biology of the cell · 2023Article
- WASH activation controls endosomal recycling and EGFR and Hippo signaling during tumor-suppressive cell competition.Nature communications · 2022Article
- Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.Scientific reports · 2022Article
- Focal adhesion-mediated cell anchoring and migration: from in vitro to in vivo.Development (Cambridge, England) · 2022Article
- Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.Nature communications · 2021Article
- Emerging roles of the MAGE protein family in stress response pathways.The Journal of biological chemistry · 2020Review
- Article
- Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.Journal of clinical immunology · 2020Article
- Persistent and polarized global actin flow is essential for directionality during cell migration.Nature cell biology · 2019Article
- WASH phosphorylation balances endosomal versus cortical actin network integrities during epithelial morphogenesis.Nature communications · 2019Article
- Wash exhibits context-dependent phenotypes and, along with the WASH regulatory complex, regulatesJournal of cell science · 2018Article
- WASH overexpression enhances cancer stem cell properties and correlates with poor prognosis of esophageal carcinoma.Cancer science · 2017Article
- Function and regulation of the Arp2/3 complex during cell migration in diverse environments.Current opinion in cell biology · 2016Review
- Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities.Nucleus (Austin, Tex.) · 2015Article
- WASP family proteins: Molecular mechanisms and implications in human disease.European journal of cell biologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Drosophila immune cells, the hemocytes, undergo four stereotypical developmental migrations to populate the embryo, where they provide immune reconnoitering, as well as a number of non-immune-related functions necessary for proper embryogenesis. Here, we describe a role for Rho1 in one of these developmental migrations in which posteriorly located hemocytes migrate toward the head. This migration requires the interaction of Rho1 with its downstream effector Wash, a Wiskott-Aldrich syndrome family protein. Both Wash knockdown and a Rho1 transgene harboring a mutation that prevents Wash binding exhibit the same developmental migratory defect as Rho1 knockdown. Wash activates the Arp2/3 complex, whose activity is needed for this migration, whereas members of the WASH regulatory complex (SWIP, Strumpellin, and CCDC53) are not. Our results suggest a WASH complex-independent signaling pathway to regulate the cytoskeleton during a subset of hemocyte developmental migrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.