Observational studyPloS one2015
Diastolic dysfunction is an independent predictor of cardiovascular events in incident dialysis patients with preserved systolic function.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- The effect of spironolactone on diastolic function in haemodialysis patients.The international journal of cardiovascular imaging · 2021Trial
- An index of left ventricular diastolic dysfunction in patients starting peritoneal dialysis might indicate mortality and peritoneal dialysis discontinuation.Clinical and experimental nephrology · 2026Article
- Lead augmented vector right T wave and elevated E/e' ratio identify hemodialysis patients at high cardiovascular risk.Kidney research and clinical practice · 2026Article
- Prognostic value of ultrafiltration rate variability in maintenance hemodialysis patients: a prospective cohort study.Frontiers of medicine · 2025Article
- Clinical impact of diastolic dysfunction and atrial fibrillation before and after initiating hemodialysis in patients with end-stage kidney disease.Renal failure · 2024Article
- Association of Lung Ultrasound B-Lines with Left Ventricular Diastolic Function in Clinically Euvolemic Haemodialysis Patients.Blood purification · 2024Article
- The mediating role of the left ventricular mass index on the relationship between the fluid balance and left ventricular diastolic function in patients with chronic kidney disease.Kidney research and clinical practice · 2024Article
- Fibroblast growth factor-23 and cardiovascular disease among prevalent hemodialysis patients focusing on residual kidney function.Frontiers in endocrinology · 2023Observational
- Left Ventricular Diastolic Dysfunction and Progression of Chronic Kidney Disease: Analysis of KNOW-CKD Data.Journal of the American Heart Association · 2022Review
- Article
- Association of Left Ventricular Diastolic Dysfunction With Cardiovascular Outcomes in Patients With Pre-dialysis Chronic Kidney Disease: Findings From KNOW-CKD Study.Frontiers in cardiovascular medicine · 2022Article
- Association between Reduced Serum Zinc and Diastolic Dysfunction in Maintenance Hemodialysis Patients.Nutrients · 2021Article
- Coronary microcirculation and left ventricular diastolic function: comparison between patients on hemodialysis and peritoneal dialysis.Journal of echocardiography · 2021Article
- Clinical significance of central systolic blood pressure in LV diastolic dysfunction and CV mortality.PloS one · 2021Observational
- Circulating Vascular Adhesion Protein-1 Level Predicts the Risk of Cardiovascular Events and Mortality in Hemodialysis Patients.Frontiers in cardiovascular medicine · 2021Article
- Key factors of diastolic dysfunction and abnormal left ventricular relaxation in diabetic rats.Journal of medical ultrasonics (2001) · 2020Article
- Long-Term Levocarnitine Ameliorates Left Ventricular Diastolic as Well as Systolic Dysfunction in Hemodialysis Patients - Multi-Center Study.Circulation reports · 2019Article
- Echocardiographic assessment of cardiac structure and function in chronic renal disease.Journal of echocardiography · 2019Review
- Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Article
- Prevalence and Outcomes of Left-Sided Valvular Heart Disease Associated With Chronic Kidney Disease.Journal of the American Heart Association · 2017Observational
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiastolic heart failure (HF), the prevalence of which is gradually increasing, is associated with cardiovascular (CV) morbidity and mortality in the general population and, more specifically, in patients with end-stage renal disease (ESRD). However, the impact of diastolic dysfunction on CV outcomes has not been studied in incident dialysis patients with preserved systolic function.
methodsThis prospective observational cohort study investigates the clinical consequence of diastolic dysfunction and the predictive power of diastolic echocardiographic parameters for CV events in 194 incident ESRD patients with normal or near normal systolic function, who started dialysis between July 2008 and August 2012.
resultsDuring a mean follow-up duration of 27.2 months, 57 patients (29.4%) experienced CV events. Compared to the CV event-free group, patients with CV events had a significantly higher left ventricular (LV) mass index, ratio of early mitral flow velocity (E) to early mitral annulus velocity (E') (E/E'), LA volume index (LAVI), deceleration time, and right ventricular systolic pressure, and a significantly lower LV ejection fraction and E'. In multivariate Cox proportional hazard analysis, E/E'>15 and LAVI>32 mL/m2 significantly predicted CV events (E/E'>15: hazard ratio [HR] = 5.40, 95% confidence interval [CI] = 2.73-10.70, P< .001; LAVI>32 mL/m2: HR = 5.56, 95% CI = 2.28-13.59, P< .001]. Kaplan-Meier analysis revealed that patients with both E/E'>15 and LAVI>32 mL/m2 had the worst CV outcomes.
conclusionAn increase in E/E' or LAVI is a significant risk factor for CV events in incident dialysis patients with preserved LV systolic function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.