Evidence map›Paper›PMID 25738948›Full record

Observational studyJournal of occupational and environmental medicine2015

The relationship between occupational metal exposure and arterial compliance.

Jason Y Y Wong, Shona C Fang, Rachel Grashow, Tianteng Fan, David C Christiani

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Journal of occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Toenail Metal Exposures in Fishermen from Bodo City, Nigeria.Bulletin of environmental contamination and toxicology · 2020
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Jason Y Y WongFrom the Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine (Dr Wong); Veterans' Affairs Palo Alto Health Care System (Dr Wong), Calif; New England Research Institute (Dr Fang), Watertown; Department of Environmental Health (Drs Fang, Grashow, Fan, and Christiani), Harvard School of Public Health; Department of Medicine (Dr Christiani), Harvard Medical School-Massachusetts General Hospital, Boston; Adheris Health (Dr Fan), Burlington, Mass.
Shona C Fang
Rachel Grashow
Tianteng Fan
David C Christiani
American Heart Association · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6M
The Cardiopulmonary Effects of Particulate ExposureR01ES009860 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1999 to 2014
$4.0M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P50ES00002NIEHS NIH HHS R01 ES009860NIEHS NIH HHS R01ES009860
6 · The paper itself

Abstract

backgroundThe objective of this study was to evaluate the relationship between cumulative occupational exposure to various metals and arterial compliance in welders.

methodsThe observational follow-up study consisted of 25 subjects. Levels of nickel (Ni), lead, cadmium, manganese, and arsenic from toenails were assessed using mass spectrometry. Arterial compliance as reflected by augmentation index (AIx) was measured using SphygmoCor Px Pulse Wave Analysis System. Linear regression models were used to assess the associations.

resultsFor every 1 unit increase in log-transformed toenail Ni, there was a statistically significant 5.68 (95% confidence interval, 1.38 to 9.98; P = 0.01) unit increase in AIx. No significant associations were found between AIx and lead, cadmium, manganese, and arsenic.

conclusionsCumulative Ni exposure is associated with increased arterial stiffness in welders and may increase risk of adverse cardiovascular outcomes.

Indexed as

AdultAir Pollutants, OccupationalArsenicComplianceFollow-Up StudiesHumansLinear ModelsMaleMetals, HeavyMiddle AgedNailsOccupational ExposureProspective StudiesVascular StiffnessAir Pollutants, OccupationalArsenicMetals, Heavy

Identifiers

PMID25738948
PMCPMC4391981
OpenAlexW2016588030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.