Evidence map›Paper›PMID 25738784›Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2015

Hypoenergetic diet-induced reductions in myofibrillar protein synthesis are restored with resistance training and balanced daily protein ingestion in older men.

Caoileann H Murphy, Tyler A Churchward-Venne, Cameron J Mitchell, Nathan M Kolar, Amira Kassis, Leonidas G Karagounis, Louise M Burke, John A Hawley, Stuart M Phillips

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Muscle Proteome Dynamics.Advances in experimental medicine and biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Caoileann H MurphyDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Tyler A Churchward-VenneDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Cameron J MitchellDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Nathan M KolarDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada;
Amira KassisNestlé Research Center, Nestec, Lausanne, Switzerland.
Leonidas G KaragounisNestlé Research Center, Nestec, Lausanne, Switzerland.
Louise M BurkeDepartment of Sports Nutrition, Australian Institute of Sport, Canberra, Australia;
John A HawleyExercise and Nutrition Research Group, School of Exercise Science, Australian Catholic University, Fitzroy, Victoria, Australia; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, United Kingdom; and.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, Ontario, Canada; phillis@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Strategies to enhance weight loss with a high fat-to-lean ratio in overweight/obese older adults are important since lean loss could exacerbate sarcopenia. We examined how dietary protein distribution affected muscle protein synthesis during energy balance (EB), energy restriction (ER), and energy restriction plus resistance training (ER + RT). A 4-wk ER diet was provided to overweight/obese older men (66 ± 4 yr, 31 ± 5 kg/m(2)) who were randomized to either a balanced (BAL: 25% daily protein/meal × 4) or skewed (SKEW: 7:17:72:4% daily protein/meal; n = 10/group) pattern. Myofibrillar and sarcoplasmic protein fractional synthetic rates (FSR) were measured during a 13-h primed continuous infusion of l-[ring-(13)C6]phenylalanine with BAL and SKEW pattern of protein intake in EB, after 2 wk ER, and after 2 wk ER + RT. Fed-state myofibrillar FSR was lower in ER than EB in both groups (P < 0.001), but was greater in BAL than SKEW (P = 0.014). In ER + RT, fed-state myofibrillar FSR increased above ER in both groups and in BAL was not different from EB (P = 0.903). In SKEW myofibrillar FSR remained lower than EB (P = 0.002) and lower than BAL (P = 0.006). Fed-state sarcoplasmic protein FSR was reduced similarly in ER and ER + RT compared with EB (P < 0.01) in both groups. During ER in overweight/obese older men a BAL consumption of protein stimulated the synthesis of muscle contractile proteins more effectively than traditional, SKEW distribution. Combining RT with a BAL protein distribution "rescued" the lower rates of myofibrillar protein synthesis during moderate ER.

Indexed as

Protein BiosynthesisResistance TrainingAgedAgingBody CompositionCaloric RestrictionDietary ProteinsDiet, ReducingEatingHumansMaleMiddle AgedMotor ActivityMuscle ProteinsMuscular AtrophyDietary ProteinsMuscle Proteinsagingenergy restrictionstable isotope

Identifiers

PMID25738784
PMCPMC4420900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.