ArticleMedicine2015
Vitamin D deficiency is an independent risk factor for urinary tract infections after renal transplants.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A scoping review of risk factors for urinary tract infections following renal transplantation.BMC urology · 2026Article
- Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism-Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer.International journal of molecular sciences · 2023Review
- 25(OH)D-but not 1,25(OH)Frontiers in medicine · 2023Article
- Association between vitamin D3 levels and frailty in the elderly: A large sample cross-sectional study.Frontiers in nutrition · 2022Article
- To D or not to D: vitamin D in hematopoietic cell transplantation.Bone marrow transplantation · 2020Review
- Evaluation of the relationship between vitamin D levels and prevalence of urinary tract infections in children.New microbes and new infections · 2020Article
- Bacteriuria and vitamin D deficiency: a cross sectional study of 385 nursing home residents.BMC geriatrics · 2019Article
- Association between vitamin D level and hematuria from a dipstick test in a large scale population based study: Korean National Health and nutrition examination survey.BMC nephrology · 2019Article
- Association between vitamin D and urinary tract infection in children.Korean journal of pediatrics · 2018Article
- Vitamin D deficiency is associated with increased risk of bacterial infections after kidney transplantation.The Korean journal of internal medicine · 2017Article
- Protective effect of 1α,25-dihydroxyvitamin D3 on effector CD4+ T cell induced injury in human renal proximal tubular epithelial cells.PloS one · 2017Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency is frequently found in patients with renal transplants (RTxs). Because vitamin D plays indispensable roles in the immune system, there may be an association between vitamin D deficiency and infection in these patients, but this has not been fully elucidated. Therefore, this study investigated the impact of pre-RTx vitamin D deficiency on urinary tract infection (UTI) development after RTx.We measured 25-hydroxyvitamin D3 (25(OH)D3) levels in 410 patients 2 weeks before they underwent RTx. Vitamin D deficiency was defined as 25(OH)D3 <10 ng/mL. The primary outcome was UTI occurrence after RTx. Cox proportional hazard analysis determined whether vitamin D deficiency was independently associated with UTI.The mean 25(OH)D3 level was 12.8 ± 6.9 ng/mL, and 171 patients (41.7%) were vitamin D deficient. During a median follow-up duration of 7.3 years, the UTI incidence was significantly higher in vitamin D-deficient patients (52 patients, 30.4%) compared with vitamin D-nondeficient patients (40 patients, 16.7%) (P = 0.001). Moreover, multivariate Cox proportional hazard analysis showed that vitamin D deficiency was an independent predictor of UTI after RTx (hazard ratio 1.81, 95% confidence interval 1.11-2.97, P = 0.02).Vitamin D deficiency was an independent risk factor for UTI after RTx; hence, determining 25(OH)D3 levels might help to predict infectious complications after RTx.
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