ReviewMetabolites2015
Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath.
Review in Metabolites, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 6 syntheses or guidelines pooled it, 237 citations in OpenAlex.
- Diagnostic Accuracy of Breath Tests to Detect Pulmonary Tuberculosis: A Systematic Review.Lung · 2025Pooled it
- Inconsistencies in predictive models based on exhaled volatile organic compounds for distinguishing between benign pulmonary nodules and lung cancer: a systematic review.BMC pulmonary medicine · 2024Pooled it
- Diagnostic Performance of Electronic Noses in Cancer Diagnoses Using Exhaled Breath: A Systematic Review and Meta-analysis.JAMA network open · 2022Pooled it
- Pooled it
- Breath based volatile organic compounds in the detection of breast, lung, and colorectal cancers: A systematic review.Cancer biomarkers : section A of Disease markers · 2017Pooled it
- Detection of cancer through exhaled breath: a systematic review.Oncotarget · 2015Pooled it
- Review
- Confounder-Invariant Representation Learning (CIRL) for Robust Olfaction with Scarce Aroma Sensor Data: Mitigating Humidity Effects in Breath Analysis.Sensors (Basel, Switzerland) · 2025Article
- Exhaled Aldehydes and Ketones as Biomarkers of Lung Cancer and Diabetes: Review of Sensor Technologies for Early Disease Diagnosis.Biosensors · 2025Review
- Review
- Development of an E-Nose System for the Early Diagnosis of Sepsis During Mechanical Ventilation: A Porcine Feasibility Study.Sensors (Basel, Switzerland) · 2025Article
- Chemical Nose-Based Non-Invasive Detection of Breast Cancer Using Exhaled Breath.Sensors (Basel, Switzerland) · 2025Article
- Graphene-Based Fiber Materials for Gas Sensing Applications: State of the Art Review.Materials (Basel, Switzerland) · 2024Review
- Multipressure Sampling for Improving the Performance of MOF-based Electronic Noses.ACS sensors · 2024Article
- Article
- Exhaled Breath Analysis Detects the Clearance ofBiomedicines · 2024Article
- A Clinical Breathomics Dataset.Scientific data · 2024Article
- ERS International Congress 2023: highlights from the Thoracic Oncology Assembly.ERJ open research · 2024Article
- Exhaled air profile in the early diagnosis of ventilator-associated pneumonia.Critical care science · 2024Article
- Acetone Detection and Classification as Biomarker of Diabetes Mellitus Using a Quartz Crystal Microbalance Gas Sensor Array.Sensors (Basel, Switzerland) · 2023Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advancements in the use of electronic-nose (e-nose) devices to analyze human breath profiles for the presence of specific volatile metabolites, known as biomarkers or chemical bio-indicators of specific human diseases, metabolic disorders and the overall health status of individuals, are providing the potential for new noninvasive tools and techniques useful to point-of-care clinical disease diagnoses. This exciting new area of electronic disease detection and diagnosis promises to yield much faster and earlier detection of human diseases and disorders, allowing earlier, more effective treatments, resulting in more rapid patient recovery from various afflictions. E-nose devices are particularly suited for the field of disease diagnostics, because they are sensitive to a wide range of volatile organic compounds (VOCs) and can effectively distinguish between different complex gaseous mixtures via analysis of electronic aroma sensor-array output profiles of volatile metabolites present in the human breath. This review provides a summary of some recent developments of electronic-nose technologies, particularly involving breath analysis, with the potential for providing many new diagnostic applications for the detection of specific human diseases associated with different organs in the body, detectable from e-nose analyses of aberrant disease-associated VOCs present in air expired from the lungs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.