ArticleMolecular and cellular biology1989
Translational control of germ cell-expressed mRNA imposed by alternative splicing: opioid peptide gene expression in rat testis.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 92 citations in OpenAlex.
- Localization of Glucagon-Like Peptide-2 Receptor Expression in the Mouse.Endocrinology · 2019Article
- ZFP91 zinc finger protein expression pattern in normal tissues and cancers.Oncology letters · 2019Article
- Regulation of male fertility by the opioid system.Molecular medicine (Cambridge, Mass.) · 2011Review
- Soluble corticotropin-releasing hormone receptor 2alpha splice variant is efficiently translated but not trafficked for secretion.Endocrinology · 2009Article
- Modulation of preoptic regulatory factor-2 (porf-2) mRNAs by castration and hypophysectomy.Endocrine · 1997Article
- Homeobox genes and male reproductive development.Journal of assisted reproduction and genetics · 1996Review
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation.The Journal of cell biology · 1992Article
- PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- A transferrinlike (hemiferrin) mRNA is expressed in the germ cells of rat testis.Molecular and cellular biology · 1991Article
- Atypical prodynorphin gene expression in corticosteroid-producing cells of the rat adrenal gland.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Proenkephalin products are stored in the sperm acrosome and may function in fertilization.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Transcription of the rat and mouse proenkephalin genes is initiated at distinct sites in spermatogenic and somatic cells.Molecular and cellular biology · 1990Article
- A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis.Molecular and cellular biology · 1990Article
- Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The three genes encoding the opioid peptide precursors (prodynorphin, proenkephalin, and proopiomelanocortin) are expressed in the rat testis. The sizes of the three opioid mRNAs in the testis differ from the sizes of the corresponding mRNAs in other rat tissues in which these genes are expressed. The smaller testicular proopiomelanocortin mRNA has previously been demonstrated to arise from alternative transcriptional initiation. In the present study, we found that the smaller testicular prodynorphin mRNA, expressed in Sertoli cells, results from alternative mRNA processing. Exon 2, which makes up 5' untranslated sequence, is removed from the mature transcript. Polysome analysis of brain and testis RNA indicates that the alteration of the prodynorphin leader sequence in the testis-specific transcript does not affect the efficiency of translation of this mRNA. The larger testicular proenkephalin transcript, expressed in developing germ cells, also results from alternative mRNA processing. Alternative acceptor site usage in the splicing of intron A results in a germ cell-specific proenkephalin transcript with a 491-nucleotide 5' untranslated leader sequence preceding the preproenkephalin-coding sequence. Polysome analysis indicates that this germ cell-specific proenkephalin mRNA is not efficiently translated. Mechanisms by which alternative mRNA splicing may serve to confer translational regulation upon the testicular proenkephalin transcript are discussed.
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