ArticlePloS one2015
Effect of dietary gluten on dendritic cells and innate immune subsets in BALB/c and NOD mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Diet, gut microbiome, and type 1 diabetes: from risk to translational opportunity.Gut microbes · 2026Review
- From gluten to therapeutics: molecular mechanisms of celiac disease and emerging alternatives to the gluten-free diet.Frontiers in pharmacology · 2026Review
- Expression of tolerogenic dendritic cells in the small intestinal tissue of patients with celiac disease.Heliyon · 2022Article
- Prevalence of haplotype DQ2/DQ8 and celiac disease in children with type 1 diabetes.Diabetology & metabolic syndrome · 2022Article
- The etiology and pathogenesis of type 1 diabetes - A personal, non-systematic review of possible causes, and interventions.Frontiers in endocrinology · 2022Review
- Gut-Ex-Vivo system as a model to study gluten response in celiac disease.Cell death discovery · 2021Article
- Diabetogenic effect of gluten in Wistar albino rats: a preliminary preclinical screening.Medicine and pharmacy reports · 2020Article
- Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosisOncotarget · 2019Review
- Article
- Parental Dietary Protein Source and the Role of CMKLR1 in Determining the Severity of Dahl Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2019Article
- A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.The EMBO journal · 2019Article
- Possible Prevention of Diabetes with a Gluten-Free Diet.Nutrients · 2018Review
- Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Obesity alters immune and metabolic profiles: New insight from obese-resistant mice on high-fat diet.Obesity (Silver Spring, Md.) · 2016Article
- Incidence of Type 1 Diabetes Is Not Increasing in a Population-Based Cohort in Olmsted County, Minnesota, USA.Mayo Clinic proceedings · 2016Article
- Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis.Current diabetes reports · 2016Review
- Flow cytometric gating for spleen monocyte and DC subsets: differences in autoimmune NOD mice and with acute inflammation.Journal of immunological methods · 2016Article
- Large Gliadin Peptides Detected in the Pancreas of NOD and Healthy Mice following Oral Administration.Journal of diabetes research · 2016Article
- Review
- The Role of Gluten in Celiac Disease and Type 1 Diabetes.Nutrients · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The innate immune system is known to play an important role in oral tolerance to dietary antigens. This is important in development of celiac disease (CD) but may also be important in type 1 diabetes (T1D), and could potentially explain the reduced incidence of T1D in mice receiving a gluten-free (GF) diet. The direct in vivo effect of gluten on innate cells, and particularly dendritic cells (DC) is not sufficiently clarified. Therefore, we wished to investigate the innate cell populations of spontaneous diabetic NOD mice and healthy BALB/c mice kept on a GF or a standard (STD) gluten containing diet. We studied, by flow cytometry and reverse transcription-quantitative polymerase chain reaction (qRT-PCR), if dietary gluten induces changes in the activation of DCs and distribution of selected innate cells in lymphoid, pancreatic and intestinal tissues in BALB/c and NOD mice. We found that a GF diet increased the percentage of macrophages in BALB/c spleen and of CD11c+ DCs in BALB/c and NOD spleen. Strictly gluten-free (SGF) diet increased the percentage of CD103+ DCs in BALB/c mice and decreased percentages of CD11b+ DCs in mesenteric and pancreatic lymph nodes in BALB/c mice. SGF diet in BALB/c mice also decreased DC expression of CD40, CCR7 and MHC-II in pancreatic lymph nodes. In conclusion, GF diet changes the composition of the innate immune system in BALB/c and NOD mice and increases expression of DC activation markers in NOD mice. These results contribute to the explanation of the low diabetes incidence in GF NOD mice. This mechanism may be important in development of type 1 diabetes, celiac disease and non-celiac gluten sensitivity.
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