ArticleJournal of clinical and diagnostic research : JCDR2015
Surrogate markers of the kidney and liver in the assessment of gestational diabetes mellitus and fetal outcome.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Serum β2-microglobulin, cystatin-C, and urinary KIM-1 as predictors of early renal impairment in women with diabetes in pregnancy: a prospective cohort study.BMC endocrine disorders · 2026Article
- Effects of Liver Enzyme Levels During Pregnancy on Birth Weight.Maternal and child health journal · 2025Article
- Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women.BMC pregnancy and childbirth · 2022Article
- The diagnostic indicators of gestational diabetes mellitus from second trimester to birth: a systematic review.Clinical diabetes and endocrinology · 2021Review
- Maternal circulating levels of some metabolic syndrome biomarkers in gestational diabetes mellitus.Endocrine · 2016Article
- Relationship between High Serum Cystatin C Levels and the Risk of Gestational Diabetes Mellitus.PloS one · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo investigate whether serum levels of butyrylcho-linesterase activity, cystatin C, and pre-albumin has the potential value as γ-glutamyl transferase in reflecting gestational diabetes mellitus and its fetal outcome. MATERIALS AND
methodsSeventy-six gestational diabetes mellitus women and 76 pregnancies with normal glucose tolerance in the second trimester were enrolled. Maternal serum parameters of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C, and pre-albumin were detected and evaluated. The pregnant complications and fetal outcome were also evaluated.
resultsLevels of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C, pre-albumin and glycemic variables were higher in the gestational diabetes mellitus patients than in the controls. Levels of butyrylcholinesterase activity were significantly correlated to the levels of fasting plasma glucose, cystatin C, and γ- glutamyl transferase (p < 0.05) in the gestational diabetes mellitus group. There were statistical differences in cases of preterm delivery, preeclampsia and postpartum hemorrhage. Higher levels of γ-glutamyl transferase and pre-albumin were risk markers for gestational diabetes mellitus (p < 0.05). The diagnosis curve demonstrated that γ-glutamyl transferase had a significant advantage over other markers (p < 0.001) but no significance compared with pre-albumin (p = 0.096). None of the detected markers showed predictive value for fetal outcome.
conclusionSerum levels of butyrylcholinesterase activity, γ-glutamyl transferase, cystatin C and pre-albumin were correlated with gestational diabetes mellitus status but not with the fetal outcome. Pre-albumin can be equivalent as γ-glutamyl transferase in reflecting the presence of gestational diabetes mellitus.
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