ArticleJournal of clinical and diagnostic research : JCDR2015
Ibuprofen-mediated reversal of fluconazole resistance in clinical isolates of Candida.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Disulfiram reverses fluconazole-resistance mediated by Cdr1 in Candida albicans and interferes with biofilm formation.Applied microbiology and biotechnology · 2026Article
- A mechanism study on the synergistic effects of rifapentine and fluconazole against fluconazole-resistantHeliyon · 2024Article
- Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles.Journal of medicinal chemistry · 2022Article
- Ketorolac-fluconazole: A New Combination Reverting Resistance inJournal of blood medicine · 2021Article
- In Vitro Antifungal Activity and Mechanism of AgMolecules (Basel, Switzerland) · 2020Article
- Pathogenesis and Clinical Relevance ofFrontiers in microbiology · 2020Review
- In Vitro Anticandidal Activity and Mechanism of a Polyoxovanadate Functionalized by Zn-Fluconazole Complexes.Molecules (Basel, Switzerland) · 2018Article
- Screening of potential genes contributing to the macrocycle drug resistance of C. albicans via microarray analysis.Molecular medicine reports · 2017Article
- An Antifungal Mechanism of Protolichesterinic Acid from the LichenFrontiers in pharmacology · 2017Article
- Effects of Aspirin as an Anti-inflammatory Drug on Azole-resistantIranian journal of public health · 2016Article
- Synergistic Effect of Fluconazole and Calcium Channel Blockers against Resistant Candida albicans.PloS one · 2016Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn view of the increasing prevalence of invasive Candidiasis in today's health-care scenario and the emergence of fluconazole resistance among clinical isolates of Candida, we sought to determine if Ibuprofen could elicit a reversal of fluconazole resistance and thereby offer a potential therapeutic breakthrough in fluconazole-resistant Candidiasis. MATERIALS AND
methodsWe selected 69 clinical isolates of Candida, which demonstrated an MIC of >32 μg/ml for fluconazole, and subjected them to broth microdilution in presence and absence of Ibuprofen.
resultsForty two of the 69 isolates (60.9%) demonstrated reversal of Fluconazole resistance with concomitant use of Ibuprofen. This was characterized by significant species-wise variation (p=0.00008), with all the C. albicans isolates and none of the C. glabrata isolates demonstrating such reversal. Only 22.2% and 37.7% of C. krusei and C. tropicalis isolates respectively showed Ibuprofen-mediated reversal of Fluconazole resistance.
conclusionSince Ibuprofen is a known efflux pump inhibitor, our findings hint at the possible mechanism of Fluconazole resistance in most of our Candida isolates and suggest a potential therapeutic alternative that could be useful in the majority of Fluconazole-resistant clinical isolates of Candida.
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