ArticleCardiorenal medicine2014
Association between the Hemoglobin Level and Cardiothoracic Ratio in Patients on Incident Dialysis.
Article in Cardiorenal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- Machine learning approaches for the mortality risk assessment of patients undergoing hemodialysis.Therapeutic advances in chronic disease · 2022Article
- Higher-order clinical risk factor interaction analysis for overall mortality in maintenance hemodialysis patients.Therapeutic advances in chronic disease · 2020Article
- Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis.Clinical and experimental nephrology · 2018Observational
- The cardiothoracic ratio and all-cause and cardiovascular disease mortality in patients undergoing maintenance hemodialysis: results of the MBD-5D study.Clinical and experimental nephrology · 2017Observational
- Association between serum aluminum levels and cardiothoracic ratio in patients on chronic hemodialysis.PloS one · 2017Article
- Association between peripheral arterial occlusive disease and cardiothoracic ratio in patients on chronic hemodialysis.Scientific reports · 2016Article
- A Higher Cardiothoracic Ratio Is Associated with 2-Year Mortality after Hemodialysis Initiation.Nephron extraArticle
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe present study explores associations between hemoglobin (Hb) levels and patients with cardiac enlargement in end-stage kidney disease (ESKD) to help prevent cardiac remodeling during the predialysis phase of chronic kidney disease (CKD).
methodsThis cross-sectional study included 2,249 patients with ESKD (age, 67 ± 13 years; male, 67%; diabetic kidney disease, 41%) who started hemodialysis (HD) between January 2006 and October 2013 at eight participating hospitals. We examined associations between Hb levels immediately before the first HD session and cardiothoracic ratios (CTRs). Clinical factors associated with the CTR were also assessed.
resultsThe mean Hb level was 8.7 ± 1.6 g/dl, and the mean and median CTRs were 55.0 and 54.7%, respectively. The correlation between the Hb level and the CTR was linear and negative (r = -0.129, p < 0.001). The mean CTR and the prevalence of patients with a CTR >50% obviously decreased with increasing Hb levels (both p < 0.001 for trend). Univariate logistic regression analysis revealed an approximately 20% reduction in the odds ratio for complicating CTRs >50% per 1 g/dl increase in Hb. Hb levels of <9 g/dl were significantly associated with CTRs >50%. Numerical and categorical Hb remained significantly associated with CTRs >50% after adjusting for confounding variables.
conclusionsLower Hb levels participate in progressive CTR enlargement in patients with ESKD, and maintaining Hb levels of >9 g/dl might help prevent cardiac remodeling during the predialysis phase of CKD.
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