Evidence map›Paper›PMID 25737584›Full record

ArticleScience signaling2015

Integrating p38α MAPK immune signals in nonimmune cells.

Sarah L Gaffen, Mandy J McGeachy

Abstract readComment
In one paragraph

Article in Science signaling, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. [Interleukin-17 promotes mouse hepatoma cell proliferation by antagonizing interferon-γ].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Sarah L GaffenDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. sarah.gaffen@pitt.edu.
Mandy J McGeachyDivision of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

Funding

Negative Control of IL-17R Signaling: Implications for Fungal ImmunityR01AI107825 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GAFFEN, SARAH L · 2014 to 2018
$1.9M
Regulation of Th17 Functions in Autoimmune CNS InflammationR01AI110822 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCGEACHY, MANDY J · 2015 to 2019
$1.7M
NIAID NIH HHS R01 AI107825NIAID NIH HHS R01 AI110822
6 · The paper itself

Abstract

A study by Huang et al. in this issue of Science Signaling highlights key roles for the mitogen-activated protein kinase p38α and the phosphatase MK1 in mediating interleukin-17-dependent pathology in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.

Indexed as

AnimalsDual Specificity Phosphatase 1Encephalomyelitis, Autoimmune, ExperimentalHumansMAP Kinase Signaling SystemMitogen-Activated Protein Kinase 14Multiple SclerosisReceptors, Interleukin-17Dual Specificity Phosphatase 1Mitogen-Activated Protein Kinase 14Receptors, Interleukin-17

Identifiers

PMID25737584
PMCPMC4805373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.