ArticleThe Journal of infectious diseases2015
A Tick Vector Transmission Model of Monocytotropic Ehrlichiosis.
Article in The Journal of infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Insights into tick-pathogen interactions - a single cell RNA sequencing approach of transcriptional changes during ehrlichial infection.bioRxiv : the preprint server for biology · 2026Article
- Behavioral manipulation ofmBio · 2025Article
- Article
- Article
- Review: Protective Immunity and Immunopathology of Ehrlichiosis.Zoonoses (Shannon, Ireland) · 2022Article
- Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis.BMC genomics · 2021Article
- Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue.The American journal of tropical medicine and hygiene · 2020Review
- Article
- The spleen microbiota of small wild mammals reveals distinct patterns with tick-borne bacteria.PLoS neglected tropical diseases · 2018Article
- Pathogen transmission in relation to duration of attachment by Ixodes scapularis ticks.Ticks and tick-borne diseases · 2018Review
- Canine infection with Borrelia burgdorferi, Dirofilaria immitis, Anaplasma spp. and Ehrlichia spp. in Canada, 2013-2014.Parasites & vectors · 2017Article
- Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent.Parasites & vectors · 2017Article
- Ehrlichioses: An Important One Health Opportunity.Veterinary sciences · 2016Review
- Value of Autopsy Emphasized in the Case Report of a Single Patient with Middle East Respiratory Syndrome.The American journal of pathology · 2016Article
- Co-Feeding Transmission of the Ehrlichia muris-Like Agent to Mice (Mus musculus).Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundEhrlichioses are emerging, tick-borne diseases distributed worldwide. Previously established animal models use needle inoculation as a mode of infection; however, there is limited representation of natural transmission in artificially inoculated models compared with transmission by the tick vector. The objective of this study was to develop a tick vector transmission animal model of ehrlichial infection using a human pathogen, Ehrlichia muris-like agent (EMLA).
methodsIxodes scapularis larvae were fed on EMLA-infected mice, and after molting, infected nymphs were used to infest naive animals.
resultsEhrlichiae were acquired by 90%-100% of feeding larvae. The majority of animals fed upon by infected nymphs developed sublethal infection with 27% lethality. Bacteria disseminated to all tissues tested with greatest bacterial loads in lungs, but also spleen, lymph nodes, liver, kidneys, brain, and bone marrow. Numerous foci of cellular infiltration, mitoses, and hepatocellular death were observed in liver. Mice infected by tick transmission developed higher antiehrlichial antibody levels than needle-inoculated animals. Tick-feeding-site reactions were observed, but there was no observed difference between animals infested with infected or uninfected ticks.
conclusionsFor the first time we were able to develop a tick transmission model with an Ehrlichia that is pathogenic for humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.