ArticleProceedings of the National Academy of Sciences of the United States of America2015
Modeling memory consolidation during posttraining periods in cerebellovestibular learning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Specific Over Nonspecific VR-Based Rehabilitation on Poststroke Motor Recovery: A Systematic Meta-analysis.Neurorehabilitation and neural repair · 2019Pooled it
- Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.iScience · 2025Article
- A normative principle governing memory transfer in cerebellar motor learning.Nature communications · 2025Article
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Emergence of syntax and word prediction in an artificial neural circuit of the cerebellum.Nature communications · 2024Article
- Short-term learning of the vestibulo-ocular reflex induced by a custom interactive computer game.Journal of neurophysiology · 2024Article
- Connectivity concepts in neuronal network modeling.PLoS computational biology · 2022Review
- Opposing actions of CRF-R1 and CB1 receptor on facial stimulation-induced MLI-PC plasticity in mouse cerebellar cortex.BMC neuroscience · 2022Article
- Adaptive control of movement deceleration during saccades.PLoS computational biology · 2021Article
- Diversity and dynamism in the cerebellum.Nature neuroscience · 2021Review
- Efficacy of spaced learning in adaptation of optokinetic response.Brain and behavior · 2021Article
- Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function.Frontiers in cell and developmental biology · 2021Article
- Intrinsic Plasticity of Cerebellar Purkinje Cells Contributes to Motor Memory Consolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Simulation of a Human-Scale Cerebellar Network Model on the K Computer.Frontiers in neuroinformatics · 2020Article
- Plasticity leading to cerebellum-dependent learning: two different regions, two different types.Pflugers Archiv : European journal of physiology · 2019Review
- Spaced training improves learning in Ts65Dn and Ube3a mouse models of intellectual disabilities.Translational psychiatry · 2019Article
- Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation.PLoS computational biology · 2019Article
- Principles of Neurorehabilitation After Stroke Based on Motor Learning and Brain Plasticity Mechanisms.Frontiers in systems neuroscience · 2019Review
- Diverse Neuron Properties and Complex Network Dynamics in the Cerebellar Cortical Inhibitory Circuit.Frontiers in molecular neuroscience · 2019Article
- The Emerging Concept of Intrinsic Plasticity: Activity-dependent Modulation of Intrinsic Excitability in Cerebellar Purkinje Cells and Motor Learning.Experimental neurobiology · 2018Review
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Long-term depression (LTD) at parallel fiber-Purkinje cell (PF-PC) synapses is thought to underlie memory formation in cerebellar motor learning. Recent experimental results, however, suggest that multiple plasticity mechanisms in the cerebellar cortex and cerebellar/vestibular nuclei participate in memory formation. To examine this possibility, we formulated a simple model of the cerebellum with a minimal number of components based on its known anatomy and physiology, implementing both LTD and long-term potentiation (LTP) at PF-PC synapses and mossy fiber-vestibular nuclear neuron (MF-VN) synapses. With this model, we conducted a simulation study of the gain adaptation of optokinetic response (OKR) eye movement. Our model reproduced several important aspects of previously reported experimental results in wild-type and cerebellum-related gene-manipulated mice. First, each 1-h training led to the formation of short-term memory of learned OKR gain at PF-PC synapses, which diminished throughout the day. Second, daily repetition of the training gradually formed long-term memory that was maintained for days at MF-VN synapses. We reproduced such memory formation under various learning conditions. Third, long-term memory formation occurred after training but not during training, indicating that the memory consolidation occurred during posttraining periods. Fourth, spaced training outperformed massed training in long-term memory formation. Finally, we reproduced OKR gain changes consistent with the changes in the vestibuloocular reflex (VOR) previously reported in some gene-manipulated mice.
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