ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2015
Carbon ion beam treatment in patients with primary and recurrent sacrococcygeal chordoma.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Application of Carbon Ion and Its Sensitizing Agent in Cancer Therapy: A Systematic Review.Frontiers in oncology · 2021Pooled it
- Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.Spine · 2016Pooled it
- Safety and Local Control of Radiation Therapy for Chordoma of the Spine and Sacrum: A Systematic Review.Spine · 2016Pooled it
- Metabolic and morphological assessment of carbon ion radiotherapy response in sacral chordoma.Physics and imaging in radiation oncology · 2026Article
- Carbon Ion and Proton Therapy in Sacral Chordoma: A Systematic Review.Journal of clinical medicine · 2025Review
- Recurrence Patterns After Resection of Sacral Chordoma: Toward an Optimized Postoperative Target Volume Definition.Cancers · 2025Article
- Multidisciplinary En-Bloc Resection of Sacral Chordoma: A Narrative Review and Illustrative Case.Journal of clinical medicine · 2025Review
- Intensity Modulated Carbon Ion Radiation Therapy Using Pencil Beam Scanning Technology for Patients With Unresectable Sacrococcygeal Chordoma.Advances in radiation oncology · 2024Article
- Radiotherapy for Mobile Spine and Sacral Chordoma: A Critical Review and Practical Guide from the Spine Tumor Academy.Cancers · 2023Review
- Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma.JAMA network open · 2022Article
- Who Will Benefit from Charged-Particle Therapy?Cancer research and treatment · 2021Review
- High-dose carbon-ion based radiotherapy of primary and recurrent sacrococcygeal chordomas: long-term clinical results of a single particle therapy center.Radiation oncology (London, England) · 2020Article
- [Chordoma: is there a molecular basis for diagnosis and treatment?]Der Pathologe · 2020Review
- Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas.The British journal of radiology · 2020Article
- Local and Distant Recurrence in Resected Sacral Chordomas: A Systematic Review and Pooled Cohort Analysis.Global spine journal · 2019Review
- Carbon Ion Radiotherapy for Patients with Extracranial Chordoma or Chondrosarcoma - Initial Experience from Shanghai Proton and Heavy Ion Center.Journal of Cancer · 2019Article
- Sacral insufficiency fractures after high-dose carbon-ion based radiotherapy of sacral chordomas.Radiation oncology (London, England) · 2018Article
- Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma.AJNR. American journal of neuroradiology · 2018Article
- Carbon Ion Radiotherapy: A Review of Clinical Experiences and Preclinical Research, with an Emphasis on DNA Damage/Repair.Cancers · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this work was to evaluate the results of high-dose radiation treatment using carbon ion therapy, alone or combined with intensity-modulated radiation treatment (IMRT), in patients with sacral chordoma. MATERIALS AND
methodsBetween 2009 and 2012, 56 patients with sacral chordoma were treated in our center. The tumor was located above S3 in 33 patients and in S3 or below in 23 patients. In all, 41 patients received radiation therapy for the primary tumor, while 15 patients were treated for the recurrent tumor. Toxicity was measured using NCI CTCAE v.4.03. Local control (LC) and overall survival (OS) were evaluated with the Kaplan-Meier method.
resultsA total of 23 patients were irradiated with carbon ions in combination with photon IMRT, while 33 received carbon ion therapy only. Forty-three patients had a macroscopic tumor at treatment start with a median tumor size (GTV) of 244 ml (range 5-1188 ml). The median total dose was 66 Gy (range 60-74 Gy; RBE). After a median follow-up time of 25 months, the 2- and 3-year local control probability was 76 % and 53 %, respectively. The overall survival rate was 100 %. Treatment for primary tumor and male patients resulted in significant better local control. No higher toxicity occurred within the follow-up time.
conclusionHigh-dose photon/carbon ion beam radiation therapy is safe and, especially for primary sacral chordomas, highly effective. A randomized trial is required to evaluate the role of primary definitive hypofractionated particle therapy compared with surgery with or without adjuvant radiotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.