ArticleScientific reports2015
Synchrotron X-ray imaging of pulmonary alveoli in respiration in live intact mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- In vivo imaging of central nervous system fluid spaces using synchrotron radiation-based micro computed tomography.Nature communications · 2026Article
- Alveolar macrophages initiate the spatially targeted recruitment of neutrophils after nanoparticle inhalation.Science advances · 2025Article
- Alveolar Microdynamics during Tidal Ventilation in Live Animals Imaged by SPring-8 Synchrotron.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multiscale stiffness of human emphysematous precision cut lung slices.Science advances · 2023Article
- Spherical alveolar shapes in live mouse lungs.Scientific reports · 2023Article
- Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.Molecular cell · 2023Article
- Deep 3D reconstruction of synchrotron X-ray computed tomography for intact lungs.Scientific reports · 2023Article
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- A maternal high-fat diet induces fetal origins of NASH-HCC in mice.Scientific reports · 2022Article
- Investigating biases in the measurement of apparent alveolar septal wall thickness with hyperpolarized 129Xe MRI.Magnetic resonance in medicine · 2020Article
- Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry.Scientific reports · 2020Article
- Preclinical hyperpolarizedNMR in biomedicine · 2020Article
- Three Alveolar Phenotypes Govern Lung Function in Murine Ventilator-Induced Lung Injury.Frontiers in physiology · 2020Article
- Alveolar dynamics during mechanical ventilation in the healthy and injured lung.Intensive care medicine experimental · 2019Review
- Comparative Assessment of Aspergillosis by Virtual Infection Modeling in Murine and Human Lung.Frontiers in immunology · 2019Article
- The micromechanics of lung alveoli: structure and function of surfactant and tissue components.Histochemistry and cell biology · 2018Review
- High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2018Review
- A Gaussian extension for Diffraction Enhanced Imaging.Scientific reports · 2018Article
- Respiratory-gated KES imaging of a rat model of acute lung injury at the Canadian Light Source.Journal of synchrotron radiation · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Despite nearly a half century of studies, it has not been fully understood how pulmonary alveoli, the elementary gas exchange units in mammalian lungs, inflate and deflate during respiration. Understanding alveolar dynamics is crucial for treating patients with pulmonary diseases. In-vivo, real-time visualization of the alveoli during respiration has been hampered by active lung movement. Previous studies have been therefore limited to alveoli at lung apices or subpleural alveoli under open thorax conditions. Here we report direct and real-time visualization of alveoli of live intact mice during respiration using tracking X-ray microscopy. Our studies, for the first time, determine the alveolar size of normal mice in respiration without positive end expiratory pressure as 58 ± 14 (mean ± s.d.) μm on average, accurately measured in the lung bases as well as the apices. Individual alveoli of normal lungs clearly show heterogeneous inflation from zero to ~25% (6.7 ± 4.7% (mean ± s.d.)) in size. The degree of inflation is higher in the lung bases (8.7 ± 4.3% (mean ± s.d.)) than in the apices (5.7 ± 3.2% (mean ± s.d.)). The fraction of the total tidal volume allocated for alveolar inflation is 34 ± 3.8% (mean ± s.e.m). This study contributes to the better understanding of alveolar dynamics and helps to develop potential treatment options for pulmonary diseases.
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