ArticleNature communications2015
Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed.
- Animal gut microbes and microbiomes in the 21st century and beyond.Science China. Life sciences · 2026Review
- Genetic Links to Gut Microbiome Variation in the Yellow-Rumped Warbler Hybrid Zone.Molecular ecology · 2026Article
- Sympatric Lepus spp. in the central Italian Alps host significantly different gut microbiotas.Scientific reports · 2026Article
- A negative binomial latent factor model for paired microbiome sequencing data.BMC bioinformatics · 2026Article
- A test for microbiome-mediated rescue via host phenotypic plasticity inProceedings. Biological sciences · 2025Article
- Transgressive hybrids as hopeful holobionts.Microbiome · 2025Article
- Eco-evolutionary dynamics of host-microbiome interactions in a natural population of closely related mouse subspecies and their hybrids.Proceedings. Biological sciences · 2024Article
- Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice.Communications biology · 2024Article
- A test for microbiome-mediated rescue via host phenotypic plasticity inbioRxiv : the preprint server for biology · 2024Article
- Tracking the hologenome dynamics in aquatic invertebrates by the holo-2bRAD approach.Communications biology · 2024Article
- Impact of captivity and natural habitats on gut microbiome in Epinephelus akaara across seasons.BMC microbiology · 2024Article
- Do genetic loci that cause reproductive isolation in the lab inhibit gene flow in nature?Evolution; international journal of organic evolution · 2024Article
- Aberrant microbiomes are associated with increased antibiotic resistance gene load in hybrid mice.ISME communications · 2024Article
- Hybridization alters red deer gut microbiome and metabolites.Frontiers in microbiology · 2024Article
- Hybridization promotes growth performance by altering rumen microbiota and metabolites in sheep.Frontiers in veterinary science · 2024Article
- Genome-wide mapping of gene-microbe interactions in the murine lung microbiota based on quantitative microbial profiling.Animal microbiome · 2023Article
- Benchmarking differential abundance analysis methods for correlated microbiome sequencing data.Briefings in bioinformatics · 2023Article
- Limited movement of an avian hybrid zone in relation to regional variation in magnitude of climate change.Molecular ecology · 2022Article
- Lack of host phylogenetic structure in the gut bacterial communities of New Zealand cicadas and their interspecific hybrids.Scientific reports · 2022Article
- Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the 'hologenomic basis of speciation'. Here we analyse the gut microbiota of two house mice subspecies, Mus musculus musculus and M. m. domesticus, across their Central European hybrid zone, in addition to hybrids generated in the lab. Hybrid mice display widespread transgressive phenotypes (that is, exceed or fall short of parental values) in a variety of measures of bacterial community structure, which reveals the importance of stabilizing selection operating on the intestinal microbiome within species. Further genetic and immunological analyses reveal genetic incompatibilities, aberrant immune gene expression and increased intestinal pathology associated with altered community structure among hybrids. These results provide unique insight into the consequences of evolutionary divergence in a vertebrate 'hologenome', which may be an unrecognized contributing factor to reproductive isolation in this taxonomic group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.