Evidence map›Paper›PMID 25737149›Full record

ArticleInvestigative ophthalmology & visual science2015

CNGB3-Achromatopsia Clinical Trial With CNTF: Diminished Rod Pathway Responses With No Evidence of Improvement in Cone Function.

Christopher Langlo, Adam Dubis, Michel Michaelides, Joseph Carroll

Abstract readLetterComment
In one paragraph

Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia.Investigative ophthalmology & visual science · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Christopher LangloDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States;
Adam DubisMoorfields Eye Hospital, London, United Kingdom; Institute of Ophthalmology, University College London, London, United Kingdom;
Michel MichaelidesMoorfields Eye Hospital, London, United Kingdom; Institute of Ophthalmology, University College London, London, United Kingdom;
Joseph CarrollDepartment of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States; Department of Ophthalmology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States; and Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.

Funding

MORPHOLOGY MODULEP30EY001931 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI LINK, BRIAN A · 1985 to 2016
$9.8M
Assessing Photoreceptor Structure and Function in Normal and Diseased RetinaeR01EY017607 · NEI · MEDICAL COLLEGE OF WISCONSIN · PI Joseph Carroll · 2008 to 2026
$8.3M
Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
NEI NIH HHS P30 EY001931NEI NIH HHS R01 EY017607NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Ciliary Neurotrophic FactorColor Vision DefectsCyclic Nucleotide-Gated Cation ChannelsFemaleHumansMaleRetinal Rod Photoreceptor CellsCiliary Neurotrophic FactorCyclic Nucleotide-Gated Cation Channels

Identifiers

PMID25737149
PMCPMC6733497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.