ReviewJournal of neuroendocrinology2015
The medial prefrontal cortex: coordinator of autonomic, neuroendocrine and behavioural responses to stress.
Review in Journal of neuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
138 citing papers in PubMed, 262 citations in OpenAlex.
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- Adaptation to Stress Switches Stress-Evoked Network Disconnection to a New Forebrain Network State.eNeuro · 2026Article
- Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.International journal of molecular sciences · 2026Article
- Limited sucrose intake produces subregion-specific remodeling of perineuronal nets in the medial prefrontal cortex.Brain structure & function · 2026Article
- Article
- Maternal deprivation and adolescent alcohol exposure induce sex-dependent alterations in stress-related behavior and lipid signaling in rats.Biology of sex differences · 2026Article
- Review
- Perceived Racial Stress Effects on Neuropsychological Functioning in African Americans are Mediated by the Brain's Reward/Safety SEEKING Systems via Neuroimmune and Neuroendocrine Pathways.Journal of racial and ethnic health disparities · 2026Article
- Evidence of central autonomic dysfunction in orthostatic hypotension of Parkinson's disease.Parkinsonism & related disorders · 2025Article
- Neural Circuit Connections and Functions of Locus Coeruleus-Norepinephrine System.International journal of molecular sciences · 2025Review
- Maladaptive Neuroplasticity Under Stress: Insights into Neuronal and Synaptic Changes in the Prefrontal Cortex.Molecular neurobiology · 2025Review
- Neural networks of the mouse visceromotor cortex.Nature · 2025Article
- Systems and Molecular Biology of Longevity and Preventive Medicine: Brain-Energy-Microbiome-Exposome Synergies in Blue Zones and the Cilento Case.International journal of molecular sciences · 2025Review
- Chronic unpredictable stress produces hyperalgesia and promotes inhibitory drive in medial prefrontal cortex.The journal of pain · 2025Article
- Antidepressant effects of ershiwei roudoukou pills and its active ingredient Macelignan: Multiple mechanisms involving oxidative stress, neuroinflammation and synaptic plasticity.Translational psychiatry · 2025Article
- Dynamics of stress-inducedNeurobiology of stress · 2025Article
- Effects of pregnancy on neuron electrophysiology in prefrontal cortex, hippocampus, and basolateral amygdala of mouse brain.Animal models and experimental medicine · 2025Article
- Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress.Journal of neuroendocrinology · 2025Review
- Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions.Brain sciences · 2025Review
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Responding to real or potential threats in the environment requires the coordination of autonomic, neuroendocrine and behavioural processes to promote adaptation and survival. These diverging systems necessitate input from the limbic forebrain to integrate and modulate functional output in accordance with contextual demand. In the present review, we discuss the potential role of the medial prefrontal cortex (mPFC) as a coordinator of behavioural and physiological stress responses across multiple temporal and contextual domains. Furthermore, we highlight converging evidence from rodent and human research indicating the necessity of the mPFC for modulating physiological energetic systems to mobilise or limit energetic resources as needed to ultimately promote behavioural adaptation in the face of stress. We review the literature indicating that glucocorticoids act as one of the primary messengers in the reallocation of energetic resources having profound effects locally within the mPFC, as well as shaping how the mPFC acts within a network of brain structures to modulate responses to stress. Finally, we discuss how both rodent and human studies point toward a critical role of the mPFC in the coordination of anticipatory responses to stress and why this distinction is an important one to make in stress neurobiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.