ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015
A link between cold environment and cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation.Molecular biology and evolution · 2018Pooled it
- Role of vitamin D receptor gene Cdx2 and Apa1 polymorphisms in prostate cancer susceptibility: a meta-analysis.BMC cancer · 2016Pooled it
- Cardio-Oncology in Cold Climates: Epidemiological Features, Bidirectional Interaction Mechanisms, and Integrated Management Strategies.Cardiovascular toxicology · 2026Review
- Contraindications to Whole-Body Cryostimulation (WBC). A position paper from the WBC Working Group of the International Institute of Refrigeration and the multidisciplinary expert panel.Frontiers in rehabilitation sciences · 2025Review
- The Effects of Environmental Factors on General Human Health: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Impact of environmental temperature on the survival outcomes of breast cancer: A SEER-based study.Breast cancer research and treatment · 2024Article
- Pathological mechanisms of cold and mechanical stress in modulating cancer progression.Human cell · 2024Review
- Industrial and Pharmaceutical Applications of Microbial Diversity of Hypersaline Ecology from Lonar Soda Crater.Current pharmaceutical biotechnology · 2024Review
- Association between Environmental Temperature and Survival in Gastroesophageal Cancers: A Population Based Study.Cancers · 2023Article
- The influence of meteorological factors and total malignant tumor health risk in Wuhu city in the context of climate change.BMC public health · 2023Article
- Tumor Temperature: Friend or Foe of Virus-Based Cancer Immunotherapy.Biomedicines · 2022Review
- Effect of environmental factors on SARS-CoV-2 infectivity in northern hemisphere countries: a 2-year data analysis.Public health · 2022Article
- Combinatorial influence of environmental temperature, obesity and cholesterol on SARS-CoV-2 infectivity.Scientific reports · 2022Article
- Association between ambient cold exposure and mortality risk in Shandong Province, China: Modification effect of particulate matter size.Frontiers in public health · 2022Article
- Multidimensional difference analysis in gastric cancer patients between high and low latitude.Frontiers in genetics · 2022Article
- Effect of cold exposure and capsaicin on the expression of histone acetylation and Toll-like receptors in 1,2-dimethylhydrazine-induced colon carcinogenesis.Environmental science and pollution research international · 2021Article
- High Temperature Drives Topoisomerase Mediated Chromosomal Break Repair Pathway Choice.Cancers · 2021Article
- The Mortality Risk and Socioeconomic Vulnerability Associated with High and Low Temperature in Hong Kong.International journal of environmental research and public health · 2020Article
- Macrophage Stimulated by Low Ambient Temperature Hasten Tumor Growth via Glutamine Production.Biomedicines · 2020Article
- Can the summer temperatures reduce COVID-19 cases?Public health · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many risk factors such as smoking and change of life style have been shown to promote genetic and adaptive epigenetic changes responsible for tumorigenesis. This study brings environmental temperature as a cancer causing factor to light. The cancer mortality rate (CMR) of a country was correlated with 17 different variables. Multivariate analysis of a total of 188 countries found that the average annual temperature (AAT) of a country might have a significant contribution to cancer death when compared with other factors such as alcohol and meat consumption. Univariate analysis found a negative correlation between AAT and CMR. All these countries were categorized into three temperature zones (zone I, -2 to 11.5 °C; number of countries, 38; zone II, 11.6 to 18.6 °C; number of countries, 32; and zone III, 18.7 to 30 °C; number of countries, 118). Out of the top-most 50 countries having the highest CMR, 26 (68.42 %), 10 (31.25 %), and 14 (11.66 %) belong to zone I, zone II, and zone III, respectively. Out of the least 50 countries having the lowest CMR, 1 (2.63 %), 4 (12.5 %), and 45 (37.5 %) belong to zone I, zone II, and zone III, respectively. CMR is low in those countries situated near to the Torrid zone (33(°) N to 23.5(°)S), but it is high for those countries situated away from these two latitudes. These data indicate that cold temperature may have a contribution in increasing tumorigenesis. High metabolic stress, which is the result of maintaining our body temperature against a cold environment, could be the possible cause for the higher cancer mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.