ArticleScientific reports2015
Identification of the optic recess region as a morphogenetic entity in the zebrafish forebrain.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 63 citations in OpenAlex.
- Ancestral organisation and asymmetric circuit architecture of the habenula revealed in a basal ray-finned fish.Brain structure & function · 2026Article
- Resolving forebrain developmental organisation by analysis of differential growth patterns.Nature communications · 2025Article
- Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala.The Journal of comparative neurology · 2025Article
- Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos.Development, growth & differentiation · 2024Article
- Neuronal chemokine concentration gradients mediate effects of embryonic ethanol exposure on ectopic hypocretin/orexin neurons and behavior in zebrafish.Scientific reports · 2023Article
- Loss ofFrontiers in neuroscience · 2023Article
- Neurogranin-like immunoreactivity in the zebrafish brain during development.Brain structure & function · 2022Article
- Developmental neuroanatomy of the rosy bitterling Rhodeus ocellatus (Teleostei: Cypriniformes)-A microCT study.The Journal of comparative neurology · 2022Article
- Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model.Frontiers in neuroanatomy · 2022Article
- Distinct Subdivisions in the Transition Between Telencephalon and Hypothalamus Produce Otp and Sim1 Cells for the Extended Amygdala in Sauropsids.Frontiers in neuroanatomy · 2022Article
- A Structural Atlas of the Developing Zebrafish Telencephalon Based on Spatially-Restricted Transgene Expression.Frontiers in neuroanatomy · 2022Article
- The Neuromeric/Prosomeric Model in Teleost Fish Neurobiology.Brain, behavior and evolution · 2022Review
- Neural substrates involved in the cognitive information processing in teleost fish.Animal cognition · 2021Review
- Neural pathways of olfactory kin imprinting and kin recognition in zebrafish.Cell and tissue research · 2021Review
- Involvement of Cxcl12a/Cxcr4b Chemokine System in Mediating the Stimulatory Effect of Embryonic Ethanol Exposure on Neuronal Density in Zebrafish Hypothalamus.Alcoholism, clinical and experimental research · 2020Article
- Article
- Mating Behavioral Function of Preoptic Galanin Neurons Is Shared between Fish with Alternative Male Reproductive Tactics and Tetrapods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Developmental Genes and Malformations in the Hypothalamus.Frontiers in neuroanatomy · 2020Review
- Conserved Genoarchitecture of the Basal Hypothalamus in Zebrafish Embryos.Frontiers in neuroanatomy · 2020Article
- Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regionalization is a critical, highly conserved step in the development of the vertebrate brain. Discrepancies exist in how regionalization of the anterior vertebrate forebrain is conceived since the "preoptic area" is proposed to be a part of the telencephalon in tetrapods but not in teleost fish. To gain insight into this complex morphogenesis, formation of the anterior forebrain was analyzed in 3D over time in zebrafish embryos, combining visualization of proliferation and differentiation markers, with that of developmental genes. We found that the region containing the preoptic area behaves as a coherent morphogenetic entity, organized around the optic recess and located between telencephalon and hypothalamus. This optic recess region (ORR) makes clear borders with its neighbor areas and expresses a specific set of genes (dlx2a, sim1a and otpb). We thus propose that the anterior forebrain (secondary prosencephalon) in teleosts contains three morphogenetic entities (telencephalon, ORR and hypothalamus), instead of two (telencephalon and hypothalamus). The ORR in teleosts could correspond to "telencephalic stalk area" and "alar hypothalamus" in tetrapods, resolving current inconsistencies in the comparison of basal forebrain among vertebrates.
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