Evidence map›Paper›PMID 25736847›Full record

ReviewUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2015

Implementation of the sFlt-1/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice.

H Stepan, I Herraiz, D Schlembach, S Verlohren, S Brennecke, F Chantraine, E Klein, O Lapaire, E Llurba, A Ramoni and 3 more

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03231657 nacompletednot on this mapstarted 2018, after this paper: background citation

Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis and Classification of PE Improves Maternal and Perinatal Outcomes in Women With the Suspicion of the Disease (EuroPE Study)

TypeinterventionalSponsorFundació Institut de Recerca de l'Hospital de la Santa Creu i Sant PauRan2018 to 2023Enrolled2,536ConditionsPreeclampsiaArmsPlacental biomarkers
NCT04855513 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial

TypeinterventionalSponsorHamad Medical CorporationRan2022 to 2023Enrolled414ConditionsPreeclampsia, Preeclampsia Severe, High Risk Pregnancy, EclampsiaArmsMetformin
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  5. Trial
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Angiogenic Biomarkers and Neonatal Outcomes in Suspected Preeclampsia: Retrospective Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

H StepanUniversity Hospital Leipzig, Department of Obstetrics, Leipzig, Germany.
I Herraiz
D Schlembach
S Verlohren
S Brennecke
F Chantraine
E Klein
O Lapaire
E Llurba
A Ramoni
M Vatish
D Wertaschnigg
A Galindo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiomarkersFemaleHumansHypertensionMembrane ProteinsPlacenta Growth FactorPractice Guidelines as TopicPredictive Value of TestsPre-EclampsiaPregnancyPregnancy ProteinsPrognosisProteinuriaReproducibility of ResultsRisk AssessmentVascular Endothelial Growth Factor Receptor-1BiomarkersFLT1 protein, humanMembrane ProteinsPGF protein, humanPIGF protein, humanPlacenta Growth FactorPregnancy ProteinsVascular Endothelial Growth Factor Receptor-1

Identifiers

PMID25736847
PMCPMC4369131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.