ArticleThe Journal of membrane biology2015
Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity.
Article in The Journal of membrane biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 26 citations in OpenAlex.
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Naphthalene Diimide-Based Metallacage as an Artificial Ion Channel for Chloride Ion Transport.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Simulation Model for the Non-Electrogenic Uniport Carrier-Assisted Transport of Ions across Lipid Membranes.Membranes · 2022Article
- Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium,Marine drugs · 2021Article
- Natural products as modulators of eukaryotic protein secretion.Natural product reports · 2020Review
- Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents.Cellular and molecular life sciences : CMLS · 2018Review
- Antimicrobial peptide cWFW kills by combining lipid phase separation with autolysis.Scientific reports · 2017Article
- Identification of new drug candidates against Borrelia burgdorferi using high-throughput screening.Drug design, development and therapy · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we use theory and modeling to investigate K(+) carrier valinomycin (Vln) as a classical anionophore. We discuss formation of the ion pair VlnK(+), Cl(-) versus encapsulation of the anion into VlnCl(-) complex as two alternative mechanisms that could account for surprisingly high anionophoretic activity of the cyclic peptide (Riddell and Zhou in J Inorg Biochem 55:55-279, 1994), meanwhile constructing kinetic models to help distinguish between the two. The study is guided by the idea to create "valinomycin for anions" and in this respect the selectivity problem is at the heart, as synthetic anionophores are expected to have the same issues with the counterion translocation as Vln has. The study helps to understand what Vln really is and so what "valinomycin for anions" has to be. Furthermore, using recent examples, we explore how Vln has been utilized as a tool for research in the two different fields, with an aim to illustrate advantages and potential of basic scientific methods over supramolecular way, celebrating victory of science over commonsense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.