ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2015
Distinct Tissue Mineral Density in Plate- and Rod-like Trabeculae of Human Trabecular Bone.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 28 citations in OpenAlex.
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- Elderly Caribbean Hispanic men have lower tibial stiffness and failure load compared to non-Hispanic White and Black men.JBMR plus · 2025Article
- Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Fractures in women with type 2 diabetes are associated with marked deficits in cortical parameters and trabecular plates.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Mechanical impact of regional structural deterioration and tissue-level compensation on proximal femur trabecular bone.Frontiers in bioengineering and biotechnology · 2024Article
- Degenerations in Global Morphometry of Cancellous Bone in Rheumatoid Arthritis, Osteoarthritis and Osteoporosis of Femoral Heads are Similar but More Severe than in Ageing Controls.Calcified tissue international · 2022Article
- Effects of Osteoporosis on Bone Morphometry and Material Properties of Individual Human Trabeculae in the Femoral Head.JBMR plus · 2021Article
- Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").Frontiers in endocrinology · 2021Review
- Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study.Frontiers in medicine · 2021Article
- Using zebrafish to study skeletal genomics.Bone · 2019Review
- Analysis of Trabecular Bone Mechanics Using Machine Learning.Evolutionary bioinformatics online · 2019Article
- Immunological and morphological analysis of heterotopic ossification differs to healthy controls.BMC musculoskeletal disorders · 2018Article
- Human bone perivascular niche-on-a-chip for studying metastatic colonization.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Three-dimensional morphometric properties of rod- and plate-like trabeculae in adolescent cancellous bone.Journal of orthopaedic translation · 2018Article
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5 authors at 1 institution in 1 country.
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Abstract
Trabecular bone quality includes both microstructural and intrinsic tissue mineralization properties. However, the tissue mineralization in individual trabeculae of different trabecular types and orientations has not yet been investigated. The aim of this study was to develop an individual trabecula mineralization (ITM) analysis technique to determine tissue mineral density (TMD) distributions in plate- and rod-like trabeculae, respectively, and to compare the TMD of trabeculae along various orientations in micro-computed tomography (μCT) images of trabecular bone samples from the femoral neck, greater trochanter, and proximal tibia. ITM analyses indicated that trabecular plates, on average, had significantly higher TMD than trabecular rods. In addition, the distribution of TMD in trabecular plates depended on trabecular orientation with the lowest TMD in longitudinal plates and the highest TMD in transverse plates. Conversely, there was a relatively uniform distribution of TMD among trabecular rods, with respect to trabecular orientation. Further analyses of TMD distribution revealed that trabecular plates had higher mean and peak TMD, whereas trabecular rods had a wider TMD distribution and a larger portion of low mineralized trabeculae. Comparison of apparent Young's moduli derived from micro-finite element models with and without heterogeneous TMD demonstrated that heterogeneous TMD in trabecular plates had a significant influence on the elastic mechanical property of trabecular bone. In conclusion, this study revealed differences in TMD between plate- and rod-like trabeculae and among various trabecular orientations. The observation of less mineralized longitudinal trabecular plates suggests interesting implications of these load-bearing plates in bone remodeling. The newly developed ITM analysis can be a valuable technique to assess the influence of metabolic bone diseases and their pharmaceutical treatments on not only microstructure of trabecular bone but also the microarchitectural heterogeneity of tissue mineralization.
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