ReviewCurrent psychiatry reports2015
Changes in comorbid conditions after prolonged exposure for PTSD: a literature review.
Review in Current psychiatry reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of psychosocial interventions for adults with substance use disorder that have a co-occurring mental health disorder: an umbrella review and illustrative cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2026Pooled it
- The Effect of Concurrent Depression on PTSD Outcomes in Trauma-Focused Psychotherapy: A Meta-Analysis of Randomized Controlled Trials.Behavior therapy · 2021Pooled it
- Therapists perspectives on the Early Intervention after Rape study: a qualitative process evaluation of a randomized controlled trial.European journal of psychotraumatology · 2025Trial
- Impact of three variants of prolonged exposure therapy on comorbid diagnoses in patients with childhood abuse-related PTSD.Cognitive behaviour therapy · 2024Trial
- Benchmarking secondary outcomes to posttraumatic stress disorder symptom change in response to cognitive processing and written exposure therapy for posttraumatic stress disorder.Journal of anxiety disorders · 2023Trial
- MassedPsychological medicine · 2023Trial
- Effects of cannabidiol on symptoms induced by the recall of traumatic events in patients with posttraumatic stress disorder.Psychopharmacology · 2022Trial
- Prolonged Exposure and Sertraline Treatments for Posttraumatic Stress Disorder Also Improve Multiple Indicators of Social Functioning.Journal of traumatic stress · 2020Trial
- Substance use disorders and PTSD: Examining substance use, PTSD symptoms, and dropout following imaginal exposure.Addictive behaviors · 2019Trial
- Trial
- Incentivizing attendance to prolonged exposure for PTSD with opioid use disorder patients: A randomized controlled trial.Journal of consulting and clinical psychology · 2017Trial
- Trauma-Focused Treatment in PTSD Patients With Psychosis: Symptom Exacerbation, Adverse Events, and Revictimization.Schizophrenia bulletin · 2016Trial
- Prolonged exposure in routine outpatient care: a naturalistic study of feasibility, safety and effectiveness.European journal of psychotraumatology · 2026Article
- Threat Sensitivity, Stress, and Alcohol Use in Probable PTSD: Findings from a Mobile Attention Bias Modification Trial.Cognitive therapy and research · 2026Article
- Posttraumatic stress disorder symptoms, posttraumatic cognitions, and dissociative experiences following rape: The roles of rape tactics and peritraumatic tonic immobility.Journal of traumatic stress · 2025Article
- The role of the first interpersonal trauma exposure's developmental period on fear regulation processes among adult women.European journal of psychotraumatology · 2025Article
- Comparing Suicide Rates for Cognitive Processing Therapy Versus Prolonged Exposure Therapy for Posttraumatic Stress Disorder.American journal of psychotherapy · 2025Article
- Co-Occurring Mental and Physical Health Conditions Among Older Adults With and Without Post-traumatic Stress Disorder: A Case Control Study.Journal of geriatric psychiatry and neurology · 2025Article
- The effectiveness of a remote intensive trauma-focused treatment programme for PTSD.European journal of psychotraumatology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Prolonged exposure (PE) is an effective psychological treatment for patients who suffer from PTSD. The majority of PTSD patients have comorbid psychiatric disorders, and some clinicians are hesitant to use PE with comorbid patients because they believe that comorbid conditions may worsen during PE. In this article, we reviewed the evidence for this question: what are the effects of PE on comorbid symptoms and associated symptomatic features? We reviewed findings from 18 randomized controlled trials of PE that assessed the most common comorbid conditions (major depression, anxiety disorders, substance use disorders, personality disorders, and psychotic disorders) and additional symptomatic features (suicidality, dissociation, negative cognitions, negative emotions, and general health and work/social functioning). Although systematic research is not available for all comorbid populations, the existing research indicates that comorbid disorders and additional symptomatic features either decline along with the PTSD symptoms or do not change as a result of PE. Therefore, among the populations that have been studied to date, there is no empirical basis for excluding PTSD patients from PE due to fear of increases in comorbid conditions or additional symptomatic features. Limitations of the existing research and recommendations for future research are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.