ArticleChemistry (Weinheim an der Bergstrasse, Germany)2015
Dual-modal magnetic resonance/fluorescent zinc probes for pancreatic β-cell mass imaging.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Molecular Imaging of In Vivo Zinc Distribution Using Nuclear and Magnetic Resonance Imaging.Chemical & biomedical imaging · 2026Review
- A Reactive and Specific Sensor for Activity-BasedACS sensors · 2024Article
- ATP-responsive Mn(II)-basedChemical communications (Cambridge, England) · 2023Article
- Diastereoselective Synthesis of α-Aryl-Substituted LnDOTA Chelates from Achiral Starting Materials by Deracemization Under Mild Conditions.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Impact of anFrontiers in endocrinology · 2023Article
- Imaging zinc trafficking in vivo by positron emission tomography with zinc-62.Metallomics : integrated biometal science · 2022Article
- Non-invasive radionuclide imaging of trace metal trafficking in health and disease: "PET metallomics".RSC chemical biology · 2022Review
- Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021Article
- A fluorescent probe for the discrimination of oxidation states of palladium.Chemical science · 2021Article
- Highly Potent MRI Contrast Agent Displaying Outstanding Sensitivity to Zinc Ions.Angewandte Chemie (International ed. in English) · 2021Article
- Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.Inorganic chemistry · 2021Article
- Smart magnetic resonance imaging-based theranostics for cancer.Theranostics · 2021Review
- From Zn(II) to Cu(II) Detection by MRI Using Metal-Based Probes: Current Progress and Challenges.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Imaging Tissue Physiology In Vivo by Use of Metal Ion-Responsive MRI Contrast Agents.Pharmaceuticals (Basel, Switzerland) · 2020Review
- Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas.Dalton transactions (Cambridge, England : 2003) · 2020Article
- Molecular imaging of β-cells: diabetes and beyond.Advanced drug delivery reviews · 2019Review
- Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for ZnJournal of the American Chemical Society · 2018Article
- Applications of Nanomaterials Based on Magnetite and Mesoporous Silica on the Selective Detection of Zinc Ion in Live Cell Imaging.Nanomaterials (Basel, Switzerland) · 2018Article
- A Ratiomeric Fluorescent Sensor for ZnJournal of fluorescence · 2017Article
- Strain Differences Determine the Suitability of Animal Models for Noninvasive In Vivo Beta Cell Mass Determination with Radiolabeled Exendin.Molecular imaging and biology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 4 countries.
Funding
Abstract
Despite the contribution of changes in pancreatic β-cell mass to the development of all forms of diabetes mellitus, few robust approaches currently exist to monitor these changes prospectively in vivo. Although magnetic-resonance imaging (MRI) provides a potentially useful technique, targeting MRI-active probes to the β cell has proved challenging. Zinc ions are highly concentrated in the secretory granule, but they are relatively less abundant in the exocrine pancreas and in other tissues. We have therefore developed functional dual-modal probes based on transition-metal chelates capable of binding zinc. The first of these, Gd⋅1, binds Zn(II) directly by means of an amidoquinoline moiety (AQA), thus causing a large ratiometric Stokes shift in the fluorescence from λem =410 to 500 nm with an increase in relaxivity from r1 =4.2 up to 4.9 mM(-1) s(-1) . The probe is efficiently accumulated into secretory granules in β-cell-derived lines and isolated islets, but more poorly by non-endocrine cells, and leads to a reduction in T1 in human islets. In vivo murine studies of Gd⋅1 have shown accumulation of the probe in the pancreas with increased signal intensity over 140 minutes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.