ArticleTuberculosis (Edinburgh, Scotland)2015
Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy.
Article in Tuberculosis (Edinburgh, Scotland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Human biomarker navigator.iMeta · 2026Review
- Tuberculosis and Cellular Metabolism: Insights into the Crosstalk Between Macrophage Immunometabolism and Muscle Dysregulation.International journal of molecular sciences · 2026Review
- Integrated metabolomic and transcriptomic analysis reveals novel plasma biomarkers and metabolic pathway dysregulation in latent tuberculosis infection.Microbiology spectrum · 2026Article
- Shared urinary metabolomic signatures as potential biomarkers for early intestinalCurrent research in parasitology & vector-borne diseases · 2026Article
- Metabolomic signatures of tuberculosis and paratuberculosis in goats revealed by high-resolution and benchtop NMR spectroscopy.Veterinary research · 2025Article
- Serum metabolic disparity between patients with lymph node tuberculosis and patients with sarcoidosis: towards differential diagnosis.BMC pulmonary medicine · 2025Article
- Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025Review
- Biomarkers in diagnosing and therapeutic monitoring of tuberculosis: a review.Annals of medicine · 2024Review
- Clinical metabolomics by NMR revealed serum metabolic signatures for differentiating sarcoidosis from tuberculosis.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Biomarker discovery for tuberculosis using metabolomics.Frontiers in molecular biosciences · 2023Review
- Discovery of serum biomarkers for diagnosis of tuberculosis by NMR metabolomics including cross-validation with a second cohort.Biomedical journal · 2022Article
- Novel Potential Diagnostic Serum Biomarkers of Metabolomics in Osteoarticular Tuberculosis Patients: A Preliminary Study.Frontiers in cellular and infection microbiology · 2022Article
- Urine NMR-based TB metabolic fingerprinting for the diagnosis of TB in children.Scientific reports · 2021Article
- Article
- Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker.Scientific reports · 2020Article
- Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children.Scientific reports · 2020Observational
- Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis.Frontiers in immunology · 2019Review
- Lactate Shuttles in Neuroenergetics-Homeostasis, Allostasis and Beyond.Frontiers in neuroscience · 2017Review
- Diagnostic 'omics' for active tuberculosis.BMC medicine · 2016Review
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Tuberculosis (TB) is a communicable disease of major global importance and causes metabolic disorder of the patients. In a previous study, we found that the plasma metabolite profile of TB patients differs from that of healthy control subjects based on nuclear magnetic resonance (NMR) spectroscopy. In order to evaluate the TB specificity of the metabolite profile, a total of 110 patients, including 40 with diabetes, 40 with malignancy, and 30 with community-acquired pneumonia (CAP), assessed by NMR spectroscopy, and compared to those of patients with TB. Based on the orthogonal partial least-squares discriminant analysis (OPLS-DA), the metabolic profiles of these diseases were significant different, as compared to the healthy controls and TB patients, respectively. The score plots of the OPLS-DA model demonstrated that TB was easily distinguishable from diabetes, CAP and malignancy. Plasma levels of ketone bodies, lactate, and pyruvate were increased in TB patient compared to healthy control, but lower than CAP and malignancy. We conclude that the metabolic profiles were TB-specific and reflected MTB infection. Our results strongly support the NMR spectroscopy-based metabolomics could contribute to an improved understanding of disease mechanisms and may offer clues to new TB clinic diagnosis and therapies.
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