ArticleJournal of feline medicine and surgery2016
Detection of feline coronavirus in cerebrospinal fluid for diagnosis of feline infectious peritonitis in cats with and without neurological signs.
Article in Journal of feline medicine and surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Clinical and imaging findings after antiviral treatment in cats with presumptive neurologic feline infectious peritonitis: 9 cases (2020-2024).Journal of veterinary internal medicine · 2026Article
- Feline Infectious Peritonitis: A Challenging Diagnostic and Therapeutic Labyrinth.Animals : an open access journal from MDPI · 2026Review
- Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and Their Housemates.Viruses · 2025Article
- Rapid Clinical Resolution and Differential Diagnosis of a Neurological Case of Feline Infectious Peritonitis (FIP) Using GS-441524.Pathogens (Basel, Switzerland) · 2025Article
- Post feline infectious peritonitis progressive hydrocephalus: a case series.Frontiers in veterinary science · 2025Article
- A review of feline infectious peritonitis virus infection.Veterinary world · 2024Review
- Review
- 2022 AAFP/EveryCat Feline Infectious Peritonitis Diagnosis Guidelines.Journal of feline medicine and surgery · 2022Review
- Feline temporal lobe epilepsy: seven cases of hippocampal and piriform lobe necrosis in England and literature review.Journal of feline medicine and surgery · 2022Review
- Neurological manifestations of coronavirus infections, before and after COVID-19: a review of animal studies.Journal of neurovirology · 2021Review
- SARS-CoV-2 on the ocular surface: is it truly a novel transmission route?The British journal of ophthalmology · 2021Review
- Clinical reasoning in feline vestibular syndrome: which presenting features are the most important?Journal of feline medicine and surgery · 2021Article
- Neuropathies and neurological dysfunction induced by coronaviruses.Journal of neurovirology · 2021Review
- Article
- Development of a recombinase polymerase amplification fluorescence assay to detect feline coronavirus.Molecular and cellular probes · 2020Article
- Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitis.Journal of feline medicine and surgery · 2020Article
- Detection of feline coronavirus RNA, spike gene mutations, and feline coronavirus antigen in macrophages in aqueous humor of cats in the diagnosis of feline infectious peritonitis.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Clinical reasoning in feline spinal disease: which combination of clinical information is useful?Journal of feline medicine and surgery · 2020Article
- Preliminary investigation on feline coronavirus presence in the reproductive tract of the tom cat as a potential route of viral transmission.Journal of feline medicine and surgery · 2020Article
- Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe objective of this study was to evaluate the sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) detecting feline coronavirus (FCoV) RNA in cerebrospinal fluid (CSF) of cats with and without neurological and/or ocular signs for the diagnosis of feline infectious peritonitis (FIP).
methodsThis prospective case-control study included 34 cats. Nineteen cats had a definitive histopathological diagnosis of FIP (seven of these with neurological and/or ocular signs), and 15 cats had other diseases but similar clinical signs (three of these with neurological and/or ocular signs). Real-time RT-PCR was performed on the CSF of all cats, and sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) were calculated.
resultsReal-time RT-PCR of CSF showed a specificity of 100% in diagnosing FIP, a sensitivity of 42.1%, a PPV of 100% and an NPV of 57.7%. The sensitivity of the real-time RT-PCR of CSF in cats with neurological and/or ocular signs was 85.7%. CONCLUSIONS AND RELEVANCE: Although it is known that RT-PCR can give false positive results, especially if performed using serum or plasma, this real-time RT-PCR detecting FCoV RNA in CSF can be considered a reliable specific tool for the diagnosis of FIP. If only cats with neurological involvement are evaluated, the sensitivity of this real-time RT-PCR in CSF is also high.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.