ArticleScientific reports2015
Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Nuclear Mechanotransduction at the Crossroads: How Membrane Receptors Remodel the Perinuclear Cytoskeleton to Drive Cancer and Disease.International journal of biological sciences · 2026Review
- Dynamic substrate topographies drive actin- and vimentin-mediated nuclear mechanoprotection events in human fibroblasts.BMC biology · 2025Article
- Nanofibrous filters: A promising solution for the efficient capture of polydisperse viral aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2025Article
- Fibrotic extracellular matrix impacts cardiomyocyte phenotype and function in an iPSC-derived isogenic model of cardiac fibrosis.Translational research : the journal of laboratory and clinical medicine · 2024Article
- IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors.Progress in retinal and eye research · 2024Review
- Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts.APL bioengineering · 2022Article
- Fabrication and characterization methods for investigating cell-matrix interactions in environments possessing spatial orientation heterogeneity.Acta biomaterialia · 2021Article
- Brick Strex: a robust device built of LEGO bricks for mechanical manipulation of cells.Scientific reports · 2021Article
- Engineering the Dynamics of Cell Adhesion Cues in Supramolecular Hydrogels for Facile Control over Cell Encapsulation and Behavior.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Protein Micropatterning in 2.5D: An Approach to Investigate Cellular Responses in Multi-Cue Environments.ACS applied materials & interfaces · 2021Article
- Nature-inspired topographies on hydroxyapatite surfaces regulate stem cells behaviour.Bioactive materials · 2021Article
- (De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.Advanced healthcare materials · 2020Review
- Potential strain-dependent mechanisms defining matrix alignment in healing tendons.Biomechanics and modeling in mechanobiology · 2018Article
- Prediction of Cell Alignment on Cyclically Strained Grooved Substrates.Biophysical journal · 2016Article
- A Robust Actin Filaments Image Analysis Framework.PLoS computational biology · 2016Article
- Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments.Cellular and molecular bioengineering · 2016Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vivo, adhesive cells continuously respond to a complex range of physical cues coming from the surrounding microenvironment by remodeling their cytoskeleton. Topographical and mechanical cues applied separately have been shown to affect the orientation of the actin stress fibers. Here we investigated the combined effects of contact guidance by topographical cues and uniaxial cyclic strain on actin cytoskeleton orientation of vascular derived cells. We devised a modular setup of stretchable circular and elliptic elastomeric microposts, capable to expose the cells to both contact guidance and uniaxial cyclic strain. A competition occurs between these cues when both contact guidance and strain are oriented along the same direction. For the first time we show that this competition originates from the distinct response of perinuclear basal and actin cap fibers: While basal fibers follow the contact guidance cue, actin cap fibers respond to the cyclic strain by strain avoidance. We also show that nuclear orientation follows actin cap fiber orientation, suggesting that actin cap fibers are responsible for cellular reorientation. Taken together, these findings may have broad implications in understanding the response of cells to combined topographical and mechanical cues.
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