ReviewPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2015
Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response.
Review in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Physiological Mechanisms Vulnerable to Alcohol-Induced Alterations: Role in Chronic Comorbidities.Comprehensive Physiology · 2025Review
- Application of Integrated Optical Density in Evaluating Insulin Expression in the Endocrine Pancreas During Chronic Ethanol Exposure and β-Carotene Supplementation: A Novel Approach Utilizing Artificial Intelligence.Pharmaceuticals (Basel, Switzerland) · 2024Article
- β-Carotene Supplementation Improves Pancreas Function during Moderate Ethanol Consumption: Initial Characterization from a Morphological Overview.International journal of molecular sciences · 2024Article
- MANF protects pancreatic acinar cells against alcohol-induced endoplasmic reticulum stress and cellular injury.Journal of hepato-biliary-pancreatic sciences · 2021Article
- What Do We Currently Know about the Pathophysiology of Alcoholic Pancreatitis: A Brief Review.Visceral medicine · 2020Review
- Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions.Gastroenterology · 2019Review
- Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.Pancreas · 2019Review
- Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis.World journal of gastrointestinal pathophysiology · 2018Review
- Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model.Cellular and molecular gastroenterology and hepatology · 2018Article
- Proteomic Study Defines How Alcohol Alters ER Structure and Redox Proteome to Trigger ER Stress and Acinar Cell Pathology in Pancreatitis.Cellular and molecular gastroenterology and hepatology · 2018Article
- The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells.Gastroenterology · 2017Article
- Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.The American journal of pathology · 2017Article
- Non-Exertional Heatstroke: A Case Report and Review of the Literature.The American journal of case reports · 2017Review
- Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment.Digestive diseases and sciences · 2017Review
- Uniting Epidemiology and Experimental Disease Models for Alcohol-Related Pancreatic Disease.Alcohol research : current reviews · 2017Review
- Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- New insights into the pathways initiating and driving pancreatitis.Current opinion in gastroenterology · 2016Article
- Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis: The Multiethnic Cohort.Pancreas · 2016Article
- General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Alcoholic pancreatitis: New insights into the pathogenesis and treatment.World journal of gastrointestinal pathophysiology · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur. However, another reason be a result of alcohol-induced activation of adaptive systems that protect the pancreas from the toxic effects of alcohol. We show that mechanisms within the unfolded protein response (UPR) of the endoplasmic reticulum (ER) that can lead to protection of the pancreas from pancreatic diseases with alcohol abuse. The remarkable ability of the pancreas to adapt its machinery to alcohol abuse using UPR systems and continue functioning is the likely reason that pancreatitis from alcohol abuse does not occur in the majority of heavy drinkers. These findings indicate that methods to enhance the protective responses of the UPR can provide opportunities for prevention and treatment of pancreatic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.