Evidence map›Paper›PMID 25736208›Full record

ArticlePlant physiology2015

MutS HOMOLOG1-derived epigenetic breeding potential in tomato.

Xiaodong Yang, Hardik Kundariya, Ying-Zhi Xu, Ajay Sandhu, Jiantao Yu, Samuel F Hutton, Mingfang Zhang, Sally A Mackenzie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Expansion of the MutS Gene Family in Plants.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Bioinformatics Analysis ofInternational journal of molecular sciences · 2023
    Article
  8. Review
  9. Triggers and mediators of epigenetic remodeling in plants.Frontiers in epigenetics and epigenomics · 2023
    Review
  10. Article
  11. Review
  12. Will epigenetics be a key player in crop breeding?Frontiers in plant science · 2022
    Review
  13. Review
  14. The TomatoGenes · 2021
    Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaodong YangLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).ORCID http://orcid.org/0000-0002-4971-2362
Hardik KundariyaLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).
Ying-Zhi XuLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).
Ajay SandhuLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).
Jiantao YuLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).
Samuel F HuttonLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).ORCID http://orcid.org/0000-0002-1635-4861
Mingfang ZhangLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.).
Sally A MackenzieLaboratory of Genetic Resources and Functional Improvement for Horticultural Plants, Department of Horticulture, Zhejiang University, Hangzhou 310029, People's Republic of China (X.Y., M.Z.);Department of Agronomy and Horticulture, University of Nebraska, Lincoln, Nebraska 68588-0660 (X.Y., H.K., Y.-Z.X., A.S., J.Y., S.A.M.); andGulf Coast Research and Education Center, Institute of Food and Agricultural Sciences, University of Florida, Wimauma, Florida 33598-6101 (S.F.H.) smackenzie2@unl.edu.ORCID http://orcid.org/0000-0003-2077-5607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence is compelling in support of a naturally occurring epigenetic influence on phenotype expression in land plants, although discerning the epigenetic contribution is difficult. Agriculturally important attributes like heterosis, inbreeding depression, phenotypic plasticity, and environmental stress response are thought to have significant epigenetic components, but unequivocal demonstration of this is often infeasible. Here, we investigate gene silencing of a single nuclear gene, MutS HOMOLOG1 (MSH1), in the tomato (Solanum lycopersicum) 'Rutgers' to effect developmental reprogramming of the plant. The condition is heritable in subsequent generations independent of the MSH1-RNA interference transgene. Crossing these transgene-null, developmentally altered plants to the isogenic cv Rutgers wild type results in progeny lines that show enhanced, heritable growth vigor under both greenhouse and field conditions. This boosted vigor appears to be graft transmissible and is partially reversed by treatment with the methylation inhibitor 5-azacytidine, implying the influence of mobile, epigenetic factors and DNA methylation changes. These data provide compelling evidence for the feasibility of epigenetic breeding in a crop plant.

Indexed as

BreedingEpigenesis, GeneticAdaptation, PhysiologicalArabidopsisCrosses, GeneticDNA MethylationGene Expression ProfilingGene Expression Regulation, PlantInheritance PatternsPhenotypePlant ProteinsPlants, Genetically ModifiedReal-Time Polymerase Chain ReactionReproductionRNA InterferenceSeedlingsPlant Proteins

Identifiers

PMID25736208
PMCPMC4424023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.