SynthesisMycopathologia2015
Systemic Review of Published Reports on Primary Cutaneous Cryptococcosis in Immunocompetent Patients.
Synthesis in Mycopathologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Primary Cutaneous Cryptococcosis in Immunocompetent Patients: Recognition and Management.American journal of clinical dermatology · 2026Review
- Post-Traumatic Primary Cutaneous Cryptococcosis Presenting as a Chronic Refractory Forearm Ulcer with Polymicrobial Coinfection: An mNGS-Assisted Case Report and Literature Review.Clinical, cosmetic and investigational dermatology · 2026Article
- Plant-derived nodule-specific cysteine-rich peptides as potent antifungal agents againstCurrent research in microbial sciences · 2025Article
- Article
- A case of primary cutaneous Cryptococcus neoformans infection.BMC infectious diseases · 2024Article
- Cryptococcosis and Cryptococcal Meningitis: A Narrative Review and the Up-to-Date Management Approach.Cureus · 2024Review
- Primary Cutaneous Cryptococcosis in an Immunocompetent Patient: Diagnostic Workflow and Choice of Treatment.Diagnostics (Basel, Switzerland) · 2023Article
- When in Doubt, Cut It Out: Biopsy as Key in Diagnosing Cryptococcal Soft Tissue Infection.Cureus · 2022Article
- Mediastinal Small Cell Carcinoma with Primary Cutaneous Cryptococcosis: A Rare Case Report.Infection and drug resistance · 2021Article
- Fulminant cryptococcal meningoencephalitis after successful treatment of primary cutaneous cryptococcosis.Germs · 2020Article
- Skin cryptococcosis in an immunocompromised renal-transplant recipient.Medical mycology case reports · 2020Article
- The Role of Testosterone and Gibberellic Acid in the Melanization ofFrontiers in microbiology · 2020Article
- Primary cutaneous cryptococcal infection due to fingolimod - Induced lymphopenia with literature review.IDCases · 2020Article
- Primary cutaneous cryptococcosis in an elderly pigeon breeder.JAAD case reports · 2019Article
- An Overview of Sex Bias inJournal of fungi (Basel, Switzerland) · 2018Review
- Asymptomatic Meningitis and Lung Cavity in a Case of Cryptococcosis.The American journal of case reports · 2017Article
- Cryptococcosis in Patients with Nephrotic Syndrome: A Pooled Analysis of Cases.Mycopathologia · 2017Article
- Primary Cutaneous Cryptococcosis: A New Case of This Rare Entity.Open forum infectious diseases · 2017Article
- Disseminated cryptococcosis with skin lesions: report of a case series.Anais brasileiros de dermatologia · 2017Article
- Primary cutaneous cryptococcal infection with subsequent erythema nodosum in a 10-year-old immunocompetent girl.JAAD case reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary cutaneous cryptococcosis (PCC) has been confirmed as a distinct clinical entity with secondary cutaneous cryptococcosis from systematic infection since 2003. Although it has been confirmed as a distinct clinical entity, little has progressed on PCC in immunocompetent hosts compared to their immunocompromised counterpart. We reviewed the literature on cases of PCC in immunocompetent patients from 2004 to 2014, and 21 cases from 16 reports were identified. Males are more likely to develop PCC infections, with a ratio of 17:4 male to female. These patients were found to be almost all senior population except for patients from Asia. Asymptomatic or moderate itching manifesting in a painful nodule is the most common presentation, although there is no typical clinical manifestation recorded. Upper limbs are the most common site of infection, accounting for 71.4 % of all patients. Of the 12 identified isolates, 6 strains are identified as C. neoformans, 5 as C. gattii, and 1 as C.laurentii. Fluconazole was used in 10 cases; however, only 80 % of the 10 cases could confirm that fluconazole was effective in clearing the infections. Interestingly although not approved as a treatment option, Itraconazole was effective in the seven cases it was used to treat cryptococcosis, with a dosage range of 100-400 mg/d and duration from 3 to 6 months. Even though the prognosis of these patients was generally good, more data are need to determine which antifungal azole is the better treatment option and whether primary skin infections could disseminate to systematic infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.