ReviewJournal of exposure science & environmental epidemiology
Challenges for environmental epidemiology research: are biomarker concentrations altered by kidney function or urine concentration adjustment?
Review in Journal of exposure science & environmental epidemiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- An updated systematic review on the association between Cd exposure, blood pressure and hypertension.Ecotoxicology and environmental safety · 2021Pooled it
- Environmental exposures and pediatric kidney function and disease: A systematic review.Environmental research · 2017Pooled it
- A Pilot Study to Explore the Application of Silicone Wristband-Based Chemical Exposure Assessment to Kidney Disease Epidemiology in Agricultural Workers.Environmental health perspectives · 2026Article
- Urine glyphosate levels and kidney function outcomes in a cohort study of workers in El Salvador and Nicaragua.Journal of exposure science & environmental epidemiology · 2026Article
- Considerations for the Analysis of Urinary Environmental Chemical Concentrations During Pregnancy.Epidemiology (Cambridge, Mass.) · 2026Article
- Toenail metal concentrations and kidney health among young people at risk of chronic kidney disease of uncertain etiology.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- The Association of Arsenic Metabolism and Blood Pressure: A Cross-Sectional Analysis in the MesoAmerican Nephropathy Occupational Study (MANOS).Research square · 2026Article
- Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM).Environment international · 2025Article
- Maternal phthalate exposure and BMI trajectory in children-an 18-year birth cohort follow-up study.Journal of exposure science & environmental epidemiology · 2024Article
- Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations.Environmental health perspectives · 2023Review
- Biomonitoring of inorganic arsenic species in pregnancy.Journal of exposure science & environmental epidemiology · 2023Review
- Article
- Metabolomic profiling to identify early urinary biomarkers and metabolic pathway alterations in autosomal dominant polycystic kidney disease.American journal of physiology. Renal physiology · 2023Article
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
- Article
- A cross-validation based approach for estimating specific gravity in elementary-school aged children using a nonlinear model.Environmental research · 2023Article
- Article
- Variability and correlations of synthetic chemicals in urine from a New York City-based cohort of pregnant women.Environmental pollution (Barking, Essex : 1987) · 2022Article
- Urinary Polycyclic Aromatic Hydrocarbons in a Longitudinal Cohort of Children with CKD: A Case of Reverse Causation?Kidney360 · 2022Article
- Organophosphate pesticides and progression of chronic kidney disease among children: A prospective cohort study.Environment international · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomonitoring has become a standard approach for exposure assessment in occupational and environmental epidemiology. The use of biological effect markers to identify early adverse changes in target organs has also become widely adopted. However, the potential for kidney function to affect biomarker levels in the body and the optimal approach to adjustment of biomarker concentrations in spot urine samples for hydration status are two important but underappreciated challenges associated with biomarker use. Several unexpected findings, such as positive associations between urine nephrotoxicant levels and estimated glomerular filtration rate (eGFR), have been reported recently in research using biomarkers. These and other findings, discussed herein, suggest an impact of kidney glomerular filtration or tubule processing on biomarker levels. This is more commonly raised in the context of decreased kidney filtration, traditionally referred to as reverse causality; however, recent data suggest that populations with normal kidney filtration may be affected as well. Misclassification bias would result if biomarkers reflect kidney function as well as either exposures or early biological effect outcomes. Furthermore, urine biomarker associations with eGFR that differ markedly by approach used to adjust for urine concentration have been reported. Associations between urine measures commonly used for this adjustment, such as urine creatinine, and specific research outcomes could alter observed biomarker associations with outcomes. Research recommendations to address the potential impact of kidney function and hydration status adjustment on biomarkers are provided, including a range of approaches to study design, exposure and outcome assessment, and adjustment for urine concentration.
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Registered trials
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