ArticleAnimal genetics2015
Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10.
Article in Animal genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 28 citations in OpenAlex.
- Integrated Genome-Wide Association Studies and Selection Signature Analysis Reveal the Genetic Architecture of the Wattle Trait in Goats.Animal genetics · 2026Article
- Decoding Complex Traits in Goats Through Genome-Wide Association Studies: Progress, Challenges, and Perspectives.International journal of molecular sciences · 2026Review
- Structural variant landscapes reveal convergent signatures of evolution in sheep and goats.Genome biology · 2024Article
- Genome-wide association study for wattles trait in the dairy goat breed.Animal biotechnology · 2023Article
- Genome-wide association analysis of nine reproduction and morphological traits in three goat breeds from Southern China.Animal bioscience · 2023Article
- Characteristics and trait preferences of West African Dwarf goat keepers in Ghana.Tropical animal health and production · 2021Article
- Genome-wide association studies of lactation yields of milk, fat, protein and somatic cell score in New Zealand dairy goats.Journal of animal science and biotechnology · 2020Article
- Genome-Wide Association Studies Identify Candidate Genes for Coat Color and Mohair Traits in the Iranian Markhoz Goat.Frontiers in genetics · 2018Article
- The Valdostana goat: a genome-wide investigation of the distinctiveness of its selective sweep regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Article
- Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of congenital appendages (wattles) on the throat of goats is supposed to be under genetic control with a dominant mode of inheritance. Wattles contain a cartilaginous core covered with normal skin resembling early stages of extremities. To map the dominant caprine wattles (W) locus, we collected samples of 174 goats with wattles and 167 goats without wattles from nine different Swiss goat breeds. The samples were genotyped with the 53k goat SNP chip for a subsequent genome-wide association study. We obtained a single strong association signal on chromosome 10 in a region containing functional candidate genes for limb development and outgrowth. We sequenced the whole genomes of an informative family trio containing an offspring without wattles and its heterozygous parents with wattles. In the associated goat chromosome 10 region, a total of 1055 SNPs and short indels perfectly co-segregate with the W allele. None of the variants were perfectly associated with the phenotype after analyzing the genome sequences of eight additional goats. We speculate that the causative mutation is located in one of the numerous gaps in the current version of the goat reference sequence and/or represents a larger structural variant which influences the expression of the FMN1 and/or GREM1 genes. Also, we cannot rule out possible genetic or allelic heterogeneity. Our genetic findings support earlier assumptions that wattles are rudimentary developed extremities.
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