Evidence map›Paper›PMID 25735878›Full record

ReviewChemical Society reviews2015

A comprehensive review of glycosylated bacterial natural products.

Sherif I Elshahawi, Khaled A Shaaban, Madan K Kharel, Jon S Thorson

Abstract readReview
In one paragraph

Review in Chemical Society reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.

0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

156 citing papers in PubMed.

  1. Article
  2. Review
  3. Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A.Angewandte Chemie (International ed. in English) · 2026
    Article
  6. Anomer-Selective Vorbrüggen Reaction for the Catalytic Synthesis of CJournal of the American Chemical Society · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Glycosylated cannabinoids meet computational enzyme design.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. NonglycosidicSynthetic and systems biotechnology · 2025
    Article
  14. Article
  15. Article
  16. 3'-RSC chemical biology · 2025
    Article
  17. Article
  18. Site-Selective C─H Bond Functionalization of Sugars.Angewandte Chemie (International ed. in English) · 2025
    Article
  19. Enzymatic Glycosylation ofBiomolecules · 2025
    Review
  20. Biosynthesis of the C-Glycosylated Depside Arenicolin B.Chembiochem : a European journal of chemical biology · 2025
    Article

96 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sherif I ElshahawiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Khaled A ShaabanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.
Madan K KharelSchool of Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA.
Jon S ThorsonDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, USA. jsthorson@uky.edu and Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY, USA.

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
In Vitro Glycorandomization of Natural ProductsR37AI052218 · NIAID · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT · 2012 to 2021
$4.0M
STUDIES ON CALICHEAMICIN BIOSYNTHESIS AND SELF RESISTANCER01CA084374 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI THORSON, JON SCOTT · 2000 to 2013
$3.6M
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1TR000117NCI NIH HHS R01 CA084374NCI NIH HHS R01 CA84374NIAID NIH HHS R37 AI052218NIAID NIH HHS R37 AI52218
6 · The paper itself

Abstract

A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is presented. This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.

Indexed as

AminoglycosidesBacteriaBiological ProductsGlycosylationMacrolidesMolecular StructureAminoglycosidesBiological ProductsMacrolidespluramycin

Identifiers

PMID25735878
PMCPMC4560691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.