Evidence map›Paper›PMID 25735849›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2015

Change in optic nerve sheath diameter as a radiological marker of outcome from endoscopic third ventriculostomy in children.

Llewellyn C Padayachy, Tracy Kilborn, Henri Carrara, Anthony A Figaji, Graham A Fieggen

Abstract read
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Machine learning for endoscopic third ventriculostomy success prediction-a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. Clinical and radiologic criteria to predict endoscopic third ventriculostomy success in non-communicating pediatric hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  3. Article
  4. Article
  5. Transorbital point-of-care ultrasound versus fundoscopic papilledema to support treatment indication for potentially elevated intracranial pressure in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  6. Article
  7. Surgical treatment of post-infectious hydrocephalus in infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  8. Use of neuroimaging measurements of optic nerve sheath diameter to assess intracranial pressure in craniosynostosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Article
  9. Diagnostic value of neuro-ophthalmological signs in cases of Chiari I malformation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Article
  10. Article
  11. Non-invasive intracranial pressure assessment.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Review
  12. High resolution transbulbar sonography in children with suspicion of increased intracranial pressure.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Article
  13. Optic nerve sheath diameter as a criterion for endoscopic third ventriculostomy failure in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015
    Article
  14. Optic nerve sheath diameter as criteria for endoscopic third ventriculostomy failure in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Llewellyn C PadayachyPaediatric Neurosurgery Unit, Division of Neurosurgery, Faculty of Health Sciences and School of Child and Adolescent Health, University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, 7700, South Africa, L.Padayachy@uct.ac.za.
Tracy Kilborn
Henri Carrara
Anthony A Figaji
Graham A Fieggen
University of Cape Town · ZARed Cross War Memorial Children's Hospital · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the value of the change in optic nerve sheath diameter (ONSD) as a radiological marker of endoscopic third ventriculostomy (ETV) outcome in children.

methodsMagnetic resonance imaging (MRI) scans of patients on whom ETVs were performed between the periods of January 2009 and June 2013 were reviewed. ONSD measurements on pre- and post-operative images were performed by two blinded observers, and the relationship between the change in these measurements and outcome from ETV were investigated. These findings were then also compared to conventional imaging features associated with ETV outcome.

resultsMRI scans of 24 patients were adequate to measure the ONSD pre- and post-operatively. In patients with successful ETV (n = 19), the mean change in ONSD was 0.73 mm and in patients with a failed ETV (n = 5), the mean change in ONSD was 0.18 mm (p = 0.0007). A change in ONSD of 7.5 % of the initial measurement demonstrated a sensitivity of 92.9 % and a sensitivity of 85.7 % for ETV outcome (area under the receiver operating characteristic curve (AUROC) = 0.96).

conclusionChange in ONSD is a useful radiological marker of ETV outcome and may be used in combination with conventional radiological parameters to aid decision-making in this difficult group of patients.

Indexed as

BiomarkersChild, PreschoolFemaleHumansHydrocephalusInfantMagnetic Resonance ImagingMaleNeuroendoscopyOptic NervePostoperative PeriodPrognosisRetrospective StudiesSensitivity and SpecificityThird VentricleTreatment OutcomeBiomarkers

Identifiers

PMID25735849
OpenAlexW1990317071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.