ArticleScientific reports2015
Quantitative detection of nitric oxide in exhaled human breath by extractive electrospray ionization mass spectrometry.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Nitric Oxide Signaling and Sensing in Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Thin Films of Chlorinated Vanadyl Phthalocyanines as Active Layers of Chemiresistive Sensors for the Detection of Ammonia.Micromachines · 2023Article
- Low-Cost Nitric Oxide Sensors: Assessment of Temperature and Humidity Effects.Sensors (Basel, Switzerland) · 2022Article
- Article
- Colorimetry-Based Detection of Nitric Oxide from Exhaled Breath for Quantification of Oxidative Stress in Human Body.Healthcare (Basel, Switzerland) · 2021Article
- Real-time toxicity prediction ofActa pharmaceutica Sinica. B · 2020Article
- Lipids in surgical aerosol as diagnosis biomarkers for discrimination of lung cancer.Cancer management and research · 2019Article
- Quantitative mass spectrometry of unconventional human biological matrices.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Online Measurement of Exhaled NO Concentration and Its Production Sites by Fast Non-equilibrium Dilution Ion Mobility Spectrometry.Scientific reports · 2016Article
- Accurate quantification of creatinine in serum by coupling a measurement standard to extractive electrospray ionization mass spectrometry.Scientific reports · 2016Article
- Fractional exhaled nitric oxide-measuring devices: technology update.Medical devices (Auckland, N.Z.) · 2016Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exhaled nitric oxide (eNO) is a useful biomarker of various physiological conditions, including asthma and other pulmonary diseases. Herein a fast and sensitive analytical method has been developed for the quantitative detection of eNO based on extractive electrospray ionization mass spectrometry (EESI-MS). Exhaled NO molecules selectively reacted with 2-phenyl-4, 4, 5, 5-tetramethylimidazoline-1-oxyl-3-oxide (PTIO) reagent, and eNO concentration was derived based on the EESI-MS response of 1-oxyl-2-phenyl-4, 4, 5, 5-tetramethylimidazoline (PTI) product. The method allowed quantification of eNO below ppb level (~0.02 ppbv) with a relative standard deviation (RSD) of 11.6%. In addition, eNO levels of 20 volunteers were monitored by EESI-MS over the time period of 10 hrs. Long-term eNO response to smoking a cigarette was recorded, and the observed time-dependent profile was discussed. This work extends the application of EESI-MS to small molecules (<30 Da) with low proton affinity and collision-induced dissociation efficiency, which are usually poorly visible by conventional ion trap mass spectrometers. Long-term quantitative profiling of eNO by EESI-MS opens new possibilities for the research of human metabolism and clinical diagnosis.
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