ArticleDrug and alcohol dependence2015
Longitudinal analysis of pain and illicit drug use behaviors in outpatients on methadone maintenance.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Analgesic Effects of Hydromorphone versus Buprenorphine in Buprenorphine-maintained Individuals.Anesthesiology · 2019Trial
- Pain in methadone patients: Time to address undertreatment and suicide risk (ANRS-Methaville trial).PloS one · 2017Trial
- Longitudinal association between pain severity and subsequent opioid use in prescription opioid dependent patients with chronic pain.Drug and alcohol dependence · 2016Trial
- Treatment barriers and preferences among veterans with chronic musculoskeletal pain and alcohol use in primary care.Psychological services · 2026Article
- Interactions Between Plant-Derived Psychoactive Substances andMolecules (Basel, Switzerland) · 2026Review
- Efficacy of Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT) in Individuals With Chronic Pain and Opioid Use Disorder: Protocol for a Randomized Clinical Trial of a Digital Cognitive Behavioral Treatment.JMIR research protocols · 2024Article
- Predictors of Suicidal Ideation and Continued Substance Use Problems Among Patients Receiving Methadone Maintenance Treatment Who Have Co-Occurring Cocaine Use Disorder.Substance use & misuse · 2024Article
- Transitioning off methadone: A qualitative study exploring why patients discontinue methadone treatment for opioid use disorder.Journal of substance use and addiction treatment · 2023Article
- Opioid Use Disorder, Sleep Deficiency, and Ventilatory Control: Bidirectional Mechanisms and Therapeutic Targets.American journal of respiratory and critical care medicine · 2022Article
- The impact of marijuana use on cocaine use outcomes among patients in methadone maintenance treatment across five trials of contingency management.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Sleep Deficiency and Opioid Use Disorder: Trajectory, Mechanisms, and Interventions.Clinics in chest medicine · 2022Review
- Association of chronic non-cancer pain status and buprenorphine treatment retention among individuals with opioid use disorder: Results from electronic health record data.Drug and alcohol dependence reports · 2022Article
- Psychological Flexibility, Pain Characteristics and Risk of Opioid Misuse in Noncancerous Chronic Pain Patients.Journal of clinical psychology in medical settings · 2021Article
- Impact of Current Pain Status on Low-Barrier Buprenorphine Treatment Response Among Patients with Opioid Use Disorder.Pain medicine (Malden, Mass.) · 2021Article
- Chronic pain, craving, and illicit opioid use among patients receiving opioid agonist therapy.Drug and alcohol dependence · 2016Article
- Pain in the management of opioid use disorder.Journal of pain research · 2016Article
- Characterizing pain and associated coping strategies in methadone and buprenorphine-maintained patients.Drug and alcohol dependence · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLittle is known about the experience of chronic pain and the occurrence of illicit drug use behaviors in the population enrolled in methadone maintenance treatment (MMT) programs.
methodsThis is a secondary analysis of longitudinal data from two MMT samples enrolled in a randomized controlled trial of hepatitis care coordination. Patients completed pain, illicit drug use, and other questionnaires at baseline and 3, 9, and 12 months later. Associations were sought over time between the presence or absence of clinically significant pain (average daily pain ≥ 4 or mean pain interference ≥ 4 during the past week) and current illicit drug use (i.e., non-therapeutic opioid, cocaine or amphetamine use identified from self-report or urine drug screening).
resultsOf 404 patients providing complete data, within-patient variability in pain and illicit drug use was high across the four assessment periods. While 263 denied pain at baseline, 118 (44.9%) later experienced clinically significant pain during ≥ 1 follow-up assessments. Of 180 patients (44.6%) without evidence of illicit drug use at baseline, only 109 (27.0%) had similar negative drug use at all follow-up assessments. Across four assessment periods, there was no significant association between pain group status and current illicit drug use.
conclusionsThis one-year longitudinal analysis did not identify a significant association between pain and illicit drug use in MMT populations. This finding conflicts with some earlier investigations and underscores the need for additional studies to clarify the complex association between pain and substance use disorders in patients in MMT program settings.
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Registered trials
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