Evidence map›Paper›PMID 25734975›Full record

ReviewNature reviews. Rheumatology2015

Tendon injury: from biology to tendon repair.

Geoffroy Nourissat, Francis Berenbaum, Delphine Duprez

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07748793 (Autologous Fat Grafting for the Treatment of Chronic Tendinopathy), which is not on this map. Cited by 242 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 2 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07748793 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Autologous Fat Grafting for the Treatment of Chronic Tendinopathy

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2026 to 2028Enrolled40ConditionsChronic TendinopathyArmsMicro-Fragmented Adipose Tissue (MFAT) injection
3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 2 syntheses or guidelines pooled it, 481 citations in OpenAlex.

  1. Pooled it
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  11. [An integrated electrical stimulation-drug iontophoresis-monitoring system for tendon injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
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  19. Myotendinous Junction development and repair.Journal of orthopaedic translation · 2026
    Review
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182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Geoffroy NourissatService de chirurgie orthopédique et traumatologique, INSERM UMR_S938, DHU i2B, Assistance Publique-Hopitaux de Paris, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, Paris 75012, France.
Francis BerenbaumService de rhumatologie, INSERM UMR_S938, DHU i2B, Assistance Publique-Hopitaux de Paris, Hôpital Saint-Antoine, 184 rue du Faubourg Saint-Antoine, Paris 75012, France.
Delphine DuprezCentre national de la recherche scientifique UMR 7622, IBPS Developmental Biology Laboratory, F-75005, Paris 5005, France.
Inserm · FRCentre National pour la Recherche Scientifique et Technique (CNRST) · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to bone and transmit forces to produce motion. Chronic and acute tendon injuries are very common and result in considerable pain and disability. The management of tendon injuries remains a challenge for clinicians. Effective treatments for tendon injuries are lacking because the understanding of tendon biology lags behind that of the other components of the musculoskeletal system. Animal and cellular models have been developed to study tendon-cell differentiation and tendon repair following injury. These studies have highlighted specific growth factors and transcription factors involved in tenogenesis during developmental and repair processes. Mechanical factors also seem to be essential for tendon development, homeostasis and repair. Mechanical signals are transduced via molecular signalling pathways that trigger adaptive responses in the tendon. Understanding the links between the mechanical and biological parameters involved in tendon development, homeostasis and repair is prerequisite for the identification of effective treatments for chronic and acute tendon injuries.

Indexed as

Acute DiseaseAnimalsBiomechanical PhenomenaCell DifferentiationChronic DiseaseCollagen Type IEvidence-Based MedicineFibroblast Growth FactorsHomeostasisHumansRegenerative MedicineSignal TransductionTendon InjuriesTendonsWound HealingCollagen Type IFibroblast Growth Factors

Identifiers

PMID25734975
OpenAlexW1987412932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.