Evidence map›Paper›PMID 25734643›Full record

ArticleSensors (Basel, Switzerland)2015

Engineering a Ca⁺⁺⁺-sensitive (bio)sensor from the pore-module of a potassium channel.

Mattia Lorenzo DiFrancesco, Sabrina Gazzarrini, Cristina Arrigoni, Giulia Romani, Gerhard Thiel, Anna Moroni

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Modular architecture of KEMBO reports · 2025
    Review
  2. Article
  3. Exploring the Viral Channel KcvThe Journal of membrane biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mattia Lorenzo DiFrancescoDepartment of Biosciences, University of Milan, Via Celoria 26, Milano 20133, Italy. mattia.difrancesco@hotmail.it.
Sabrina GazzarriniDepartment of Biosciences, University of Milan, Via Celoria 26, Milano 20133, Italy. sabrina.gazzarrini@unimi.it.
Cristina ArrigoniDepartment of Biosciences, University of Milan, Via Celoria 26, Milano 20133, Italy. cristina.arrigoni@ucsf.edu.
Giulia RomaniInstitute of Biophysics-Milan section, National Research Council, Via Celoria 26, Milano 20133, Italy. giulia.romani@unimi.it.
Gerhard ThielDepartment of Biology, Technische Universität Darmstadt, Schnittspahnstrasse 3, Darmstadt 64287, Germany. thiel@bio.tu-darmstadt.de.
Anna MoroniDepartment of Biosciences, University of Milan, Via Celoria 26, Milano 20133, Italy. anna.moroni@unimi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Signals recorded at the cell membrane are meaningful indicators of the physiological vs. pathological state of a cell and will become useful diagnostic elements in nanomedicine. In this project we present a coherent strategy for the design and fabrication of a bio-nano-sensor that monitors changes in intracellular cell calcium concentration and allows an easy read out by converting the calcium signal into an electrical current in the range of microampere that can be easily measured by conventional cell electrophysiology apparatus.

Indexed as

Biosensing TechniquesCalciumCalcium SignalingMembrane PotentialsPotassium ChannelsCalciumPotassium Channels

Identifiers

PMID25734643
PMCPMC4435187

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.