ArticlePloS one2015
Is metabolic syndrome predictive of prevalence, extent, and risk of coronary artery disease beyond its components? Results from the multinational coronary CT angiography evaluation for clinical outcome: an international multicenter registry (CONFIRM).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Metabolic Syndrome and Coronary Artery Disease Risk: A Meta-Analysis of Observational Studies.International journal of environmental research and public health · 2021Pooled it
- Is all physical activity equal? Investigating the total and domain-specific relationships between physical activity and cardiometabolic health in U.S. adults (NHANES 2013-2018).BMC public health · 2024Article
- Atherosclerosis evaluation and cardiovascular risk estimation using coronary computed tomography angiography.European heart journal · 2024Review
- Sex-specific effects of acute chlordane exposure in the context of steatotic liver disease, energy metabolism and endocrine disruption.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Article
- Independent association between age- and sex-specific metabolic syndrome severity score and cardiovascular disease and mortality.Scientific reports · 2023Article
- Intracellular CaJournal of cardiovascular translational research · 2022Article
- Clinical profile and outcome of patients with chronic inflammatory arthritis and metabolic syndrome.Internal and emergency medicine · 2021Article
- Computed tomography findings of metabolic syndrome in patients with acute colonic diverticulitis.Journal of medical imaging and radiation oncology · 2021Article
- Cardiometabolic risk factors and survival after cancer in the Women's Health Initiative.Cancer · 2021Article
- Novel plasma biomarkers improve discrimination of metabolic health independent of weight.Scientific reports · 2020Article
- Metabolic Syndrome and Colorectal Cancer Risk: Results of Propensity Score-Based Analyses in a Community-Based Cohort Study.International journal of environmental research and public health · 2020Article
- Prevalence of high-risk coronary plaques in patients with and without metabolic syndrome and the relationship with prognosis.BMC cardiovascular disorders · 2020Article
- Circulating microparticle subpopulation in metabolic syndrome: relation to oxidative stress and coagulation markers.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Management of acute coronary syndrome in emergency departments: a cross sectional multicenter study (Tunisia).BMC emergency medicine · 2018Article
- Obesity paradox among elderly patients with coronary artery disease undergoing non-cardiac surgery.Journal of geriatric cardiology : JGC · 2018Article
- Diagnostic imaging in the management of patients with metabolic syndrome.Translational research : the journal of laboratory and clinical medicine · 2018Review
- Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease.Cardiovascular diabetology · 2016Article
- The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study.Cardiovascular diabetology · 2016Article
- Pattern of circulating microparticles in chronic heart failure patients with metabolic syndrome: Relevance to neurohumoral and inflammatory activation.BBA clinical · 2015Article
- The Relationship of Metabolic Syndrome with Stress, Coronary Heart Disease and Pulmonary Function--An Occupational Cohort-Based Study.PloS one · 2015Article
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Authors and funding
32 authors at 20 institutions in 9 countries.
Funding
Abstract
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥ 64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n = 690) were matched 1:1:1 to those with 1 component (n = 690) and 2 components (n = 690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of metabolic syndrome manifested lower rates of obstructive 1-, 2-, and 3-vessel/left main disease compared to metabolic syndrome patients (9.4% vs 13.8%, 2.6% vs 4.5%, and 1.0% vs 2.3%, respectively; p < 0.05), while those with 2 components did not (10.5% vs 13.8%, 2.8% vs 4.5% and 1.3% vs 2.3%, respectively; p > 0.05). At 2.5 years, metabolic syndrome patients experienced a higher rate of MACE compared to patients with 1 component (4.4% vs 1.6%; p = 0.002), while no difference observed compared to individuals with 2 components (4.4% vs 3.2% p = 0.25) of metabolic syndrome. In conclusion, Metabolic syndrome patients have significantly greater prevalence, severity, and prognosis of CAD compared to patients with 1 but not 2 components of metabolic syndrome.
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