SynthesisPloS one2015
Prevalence of vitamin D deficiency in sickle cell disease: a systematic review.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04662476 (Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vitamin D Supplementation on Sickle Cell Disease Hospitalisation and Related Complications Among Children in Mulago Hospital: A Randomised Clinical Trial
Who cites it
36 citing papers in PubMed, 73 citations in OpenAlex.
- Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease.Blood advances · 2018Trial
- Article
- Comparative analysis of serum vitamin D and haematological parameters among paediatric sickle cell and non-sickle cell patients at a teaching hospital in Accra, Ghana: a case-control study.BMC pediatrics · 2026Article
- Vitamin D deficiency in sickle cell disease: a neglected comorbidity in Tunisia.Annals of hematology · 2026Article
- Vitamin D Deficiency and Its Hematological Correlates in Patients with Sickle Cell Disease at a Ugandan Clinic.Journal of blood medicine · 2026Article
- Influence of hydroxyurea on tubular phosphate handling in sickle cell nephropathy.Hematology, transfusion and cell therapy · 2024Article
- Vitamin D Deficiency and Avascular Necrosis in Patients With Sickle Cell Disease: A Retrospective Cohort Study.Cureus · 2024Article
- Random Occurrence or Real Association? Primary Hyperparathyroidism in a Young Man With Sickle Cell Disease.JCEM case reports · 2024Article
- Bone Health Impairment in Patients with Hemoglobinopathies: From Biological Bases to New Possible Therapeutic Strategies.International journal of molecular sciences · 2024Review
- Endocrinopathies in Hemoglobinopathies: What Is the Role of Iron?International journal of molecular sciences · 2023Review
- Review
- Clinical Vignettes, Part II: Eyes, Teeth, and Bone.Hematology/oncology clinics of North America · 2022Review
- Perspectives: on Precision Nutrition Research in Heart, Lung, and Blood Diseases and Sleep Disorders.Advances in nutrition (Bethesda, Md.) · 2022Article
- Retinol Binding Protein, Sunlight Hours, and the Influenza Virus-Specific Immune Response.Biomedicines · 2022Article
- Article
- Hypothesis: Low Vitamin A and D Levels Worsen Clinical Outcomes When Children with Sickle Cell Disease Encounter Parvovirus B19.Nutrients · 2022Article
- Vitamin D level, lipid profile, and vitamin D receptor and transporter gene variants in sickle cell disease patients from Kurdistan of Iraq.Journal of clinical laboratory analysis · 2021Article
- Mechanisms of Bone Impairment in Sickle Bone Disease.International journal of environmental research and public health · 2021Review
- Total hip arthroplasty for sickle cell osteonecrosis: guidelines for perioperative management.EFORT open reviews · 2020Review
- Development of Algorithm for Clinical Management of Sickle Cell Bone Disease: Evidence for a Role of Vertebral Fractures in Patient Follow-up.Journal of clinical medicine · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency has emerged as a public health focus in recent years and patients with sickle cell disease (SCD) reportedly have a high prevalence of the condition. Our objectives were to summarize definitions of vitamin D deficiency and insufficiency used in the literature, and to determine the prevalence and magnitude of each in patients with SCD through a systematic review conducted according to PRISMA guidelines. From a PubMed search, 34 potential articles were identified and 15 met eligibility criteria for inclusion. Definitions of deficiency and insufficiency varied greatly across studies making direct comparisons difficult. This review provides evidence to suggest that suboptimal vitamin D levels are highly prevalent among those with SCD, far more so than in comparable non-SCD patients or matched control populations. Defining deficiency as vitamin D < 20 ng/mL, prevalence estimates in SCD populations range from 56.4% to 96.4%. When compared with results from the population-based National Health and Nutrition Examination Survey, however, the general African American population appeared to have a similarly high prevalence of vitamin D deficiency. African American patients with and without SCD were both substantially higher than that of Caucasians. What remains to be determined is whether there are adverse health effects for patients with SCD because of concurrent vitamin D deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.