Evidence map›Paper›PMID 25734565›Full record

ReviewNutrients2015

Emphasizing the health benefits of vitamin D for those with neurodevelopmental disorders and intellectual disabilities.

William B Grant, Sunil J Wimalawansa, Michael F Holick, John J Cannell, Pawel Pludowski, Joan M Lappe, Mary Pittaway, Philip May

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Vitamin DLife (Basel, Switzerland) · 2023
    Article
  11. Vitamin D Measurement: Clinical Practice and Research Implications.The journal for nurse practitioners : JNP · 2023
    Article
  12. Article
  13. An investigation of vitamin D nutritional status in children after outbreak of coronavirus disease 2019.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Article
  14. Article
  15. Vitamin D and cardiovascular disease in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2019
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

William B GrantSunlight, Nutrition, and Health Research Center, PO Box 641603, San Francisco, CA 94164-1603, USA. wbgrant@infionline.net.
Sunil J WimalawansaDepartment of Medicine & Endocrinology, Cardio Metabolic Institute, Somerset, NJ 08873, USA. suniljw@hotmail.com.
Michael F HolickDepartment of Medicine, Section of Endocrinology, Nutrition, and Diabetes, and the Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA. mfholick@bu.edu.
John J CannellVitamin D Council and San Luis Obispo Integrative Medicine, San Luis Obispo, CA 93401, USA. jjcannell@vitamindcouncil.org.
Pawel PludowskiDepartment of Biochemistry, Radioimmunology, and Experimental Medicine, The Children's Memorial Health Institute, 04-730 Warsaw, Poland. pludowski@yahoo.com.
Joan M LappeCreighton University School of Medicine, Omaha, NE 68131, USA. joanlappe@creighton.edu.
Mary PittawayGlobal Clinical Advisor-Health Promotion, Special Olympics International and Affiliate Faculty, College of Education and Human Sciences, University of Montana, Missoula, MT 59812, USA. mpitt59802@aol.com.
Philip MayInternational Foundation for Chronic Disabilities, Inc., PO Box 166, Oxford, NJ 07863, USA. pmay1@mindspring.com.
Boston University · USChildren's Memorial Health Institute · PLCreighton University · USSomerset Medical Center · USSpecial Olympics · USSunlight Nutrition and Health Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People with neurodevelopmental disorders and intellectual disabilities have much greater health care needs. Mainly staying indoors, such people generally have low 25-hydroxyvitamin D (25(OH)D) concentrations. The Vitamin D Task Force of the American Academy of Developmental Medicine and Dentistry (AADMD) reviewed the evidence of 25(OH)D concentrations that benefit the health of persons with developmental disabilities. Maintaining recommended optimal serum 25(OH)D concentrations year long will benefit skeletal development in infants, children, and adolescents, and benefit musculoskeletal health and neuromuscular coordination in adult patients, and decrease risk of falls. Maintaining optimal concentrations decreases risks and severities of autoimmune diseases, cardiovascular disease, many types of cancer, dementia, types 1 and 2 diabetes mellitus, and respiratory tract infections. Other benefits include improved dental and oral health and improved physical performance. The Task Force recommends that 25(OH)D concentrations for optimal health to be in the range of 75 to 125 nmol/L, which can be achieved using between 800 and 4000 IU/day vitamin D3 and sensible exposure to solar UVB radiation. The paper also discusses the potential risks of higher 25(OH)D concentrations, the evidence from and limitations of randomized controlled trials, and the recommendations by various groups and agencies.

Indexed as

Developmental DisabilitiesHealthIntellectual DisabilityDietary SupplementsHumansSunlightVitamin DVitamin D DeficiencyVitamins25-hydroxyvitamin DVitamin DVitamins

Identifiers

PMID25734565
PMCPMC4377865
OpenAlexW2028897817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.