ArticleTranslational psychiatry2015
Total serum cholesterol, atherogenic indices and their longitudinal association with depressive symptoms among US adults.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Mental health and quality of life in different obesity phenotypes: a systematic review.Health and quality of life outcomes · 2022Pooled it
- High-dose atorvastatin improves vascular endothelial function in patients with leukoaraiosis.Journal of clinical laboratory analysis · 2020Trial
- Assessing biological pathways in the longitudinal association between neighborhood environment and depressive symptoms.Journal of affective disorders · 2026Article
- A next-generation probiotic strain for gut health: Bacteroides cellulosilyticus LYH2 variant with anti-inflammatory and metabolic advantages.EBioMedicine · 2026Article
- Serum lipid profiles and risk of depression: a UK Biobank prospective cohort study.Frontiers in nutrition · 2026Article
- Prevalence and risk factors for depression in somatic symptom disorder patients: a cross-sectional clinical study in China.BMC psychiatry · 2025Article
- Association Between Depressive Symptoms and Blood Biomarkers in Adult Hospitalized Patients: A Multicenter Analysis Across Hospital Districts in Luzhou, China.Journal of multidisciplinary healthcare · 2025Article
- Article
- Association between dyslipidemia and depression: a cross-sectional analysis of NHANES data from 2007 to 2018.BMC psychiatry · 2024Article
- Longitudinal association of homocysteine with depressive and anxiety symptoms among urban adults: healthy aging in neighborhoods of diversity across the life span study.Translational psychiatry · 2024Article
- Association between depression and infertility risk among American women aged 18-45 years: the mediating effect of the NHHR.Lipids in health and disease · 2024Article
- Lipids in Psychiatric Disorders: Functional and Potential Diagnostic Role as Blood Biomarkers.Metabolites · 2024Review
- Association of mental disorders with sepsis: a bidirectional Mendelian randomization study.Frontiers in public health · 2024Article
- The relationship between dietary lipophilic index and load with depression, anxiety, and stress symptoms.BMC psychiatry · 2023Article
- Association between thyroid dysfunction, metabolic disturbances, and clinical symptoms in first-episode, untreated Chinese patients with major depressive disorder: Undirected and Bayesian network analyses.Frontiers in endocrinology · 2023Article
- Associations between race, APOE genotype, cognition, and mortality among urban middle-aged white and African American adults.Scientific reports · 2021Article
- The Association of Metabolic Dysfunction and Mood Across Lifespan Interacts With the Default Mode Network Functional Connectivity.Frontiers in aging neuroscience · 2021Article
- The role of lipoprotein profile in depression and cognitive performance: a network analysis.Scientific reports · 2020Article
- Systemic inflammation is associated with depressive symptoms differentially by sex and race: a longitudinal study of urban adults.Molecular psychiatry · 2020Article
- Association between epigenetic age acceleration and depressive symptoms in a prospective cohort study of urban-dwelling adults.Journal of affective disorders · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Serum cholesterol, both total and lipoprotein fractions, has been associated with mid- and late-life depression. Using longitudinal data on a large and ethnically diverse sample of urban adults, the associations of serum lipid profile measured by high or low total cholesterol (TC; >200 mg dl(-1); <160 mg dl(-1)) and by atherogenic indices, namely high total cholesterol and low-density lipoprotein cholesterol relative to high-density lipoprotein cholesterol, with change in total and domain-specific depressive symptoms over time were examined. Findings were compared by sex. (Hypothesis 1) In addition, baseline depressive symptoms as predictors for longitudinal change in lipid profile trajectory were tested. (Hypothesis 2) Mixed-effects regression analyses stratified by sex was used. Sample sizes of participants (n) and repeated observations (n') were: Hypothesis 1 (Men: n=826 ; n'=1319; Women: n=1099 ; n'=1817); Hypothesis 2 (Men: n=738; n'=1230; Women: n=964; n'=1678). As hypothesized, a higher level of atherogenic indices was linked to faster increase in depressive symptom scores, particularly depressed affect and interpersonal problems, though this relationship was found only among women. Among men a U-shaped relationship between baseline TC and longitudinal increase in somatic complaints and a direct link between low TC and longitudinal putative improvement in positive affect was found. On excluding statin users among women, low TC was associated with slower increase in depressed affect over time, whereas high TC was associated with faster increase in interpersonal problems. In summary, atherogenic indices were directly linked to faster increase in depressive symptoms among women only. More studies are needed to explain these sex-specific associations.
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