ArticleMetabolites2015
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output.
Article in Metabolites, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Metabolomics in Exercise and Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool.Scientific reports · 2022Trial
- Review
- Evaluating urinary metabolic profiles with wildland-urban-interface (wui) fire exposure among male firefighters: a comparison with municipal structure fires (msf).Environmental health : a global access science source · 2025Article
- Sample Preparation for Metabolomic Analysis in Exercise Physiology.Biomolecules · 2024Review
- Effects of exposure to trihalomethanes in swimming pool waters on metabolomics profile: a randomized parallel design trial.Journal of environmental health science & engineering · 2024Article
- Acute effects of moderate vs. vigorous endurance exercise on urinary metabolites in healthy, young, physically active men-A multi-platform metabolomics approach.Frontiers in physiology · 2023Article
- Acute enteric-coated sodium bicarbonate has negligible effect on anaerobic performance but affects metabolomics and attenuates the gastrointestinal response.Frontiers in physiology · 2022Article
- Beetroot juice - a suitable post-marathon metabolic recovery supplement?Journal of the International Society of Sports Nutrition · 2021Review
- Comparison of the Metabolites of Water Polo Players before and after Competition by the Metabolomic Approach.Journal of healthcare engineering · 2021Article
- Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats.Metabolites · 2020Article
- Article
- The unaided recovery of marathon-induced serum metabolome alterations.Scientific reports · 2020Article
- Metabolite Concentration Changes in Humans After a Bout of Exercise: a Systematic Review of Exercise Metabolomics Studies.Sports medicine - open · 2020Review
- Commentary: Metabolomics-Based Studies Assessing Exercise-Induced Alterations of the Human Metabolome: A Systematic Review.Frontiers in physiology · 2020Article
- Identification of a select metabolite panel for measuring metabolic perturbation in response to heavy exertion.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype.Metabolites · 2018Article
- Probiotic supplementation in trained trotter horses: effect on blood clinical pathology data and urine metabolomic assessed in field.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study.Environment international · 2018Article
- Response of Gut Microbiota to Metabolite Changes Induced by Endurance Exercise.Frontiers in microbiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology. We conducted an exploratory untargeted liquid chromatography mass spectrometry study to investigate the effects of a one-h aerobic exercise session in the urine of three physically active males. Individual urine samples were collected over a 37-h protocol (two pre-exercise and eight post-exercise). Raw data were subjected to a variety of normalization techniques, with the most effective measure dividing each metabolite by the sum response of that metabolite for each individual across the 37-h protocol expressed as a percentage. This allowed the metabolite responses to be plotted on a normalised scale. Our results highlight significant metabolites located in the following systems: purine pathway, tryptophan metabolism, carnitine metabolism, cortisol metabolism, androgen metabolism, amino acid oxidation, as well as metabolites from the gastrointestinal microbiome. Many of the significant changes observed in our pilot investigation mirror previous research studies, of various methodological designs, published within the last 15 years, although they have never been reported at the same time in a single study.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.