ArticleOpen forum infectious diseases2014
Mumps serum antibody levels before and after an outbreak to assess infection and immunity in vaccinated students.
Article in Open forum infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Mumps vaccination and immune status among Japanese university students: A multicenter cross-sectional study.Journal of public health research · 2024Article
- Seroprevalence of anti-mumps virus IgG antibody titer and voluntary mumps vaccination coverage in young adults in Japan.Human vaccines & immunotherapeutics · 2021Article
- Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China.Journal of immunology research · 2020Article
- Article
- Spatial, temporal, and spatiotemporal analysis of mumps in Guangxi Province, China, 2005-2016.BMC infectious diseases · 2018Article
- Baseline antibody level may help predict the risk of active human cytomegalovirus infection in a HCMV seropositive population.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Mumps transmission in social networks: a cohort study.BMC infectious diseases · 2017Article
- Mumps virus pathogenesis: Insights and knowledge gaps.Human vaccines & immunotherapeutics · 2016Article
- Dynamics of the serologic response in vaccinated and unvaccinated mumps cases during an epidemic.Human vaccines & immunotherapeutics · 2015Observational
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince 2009, various mumps outbreaks have occurred in the Netherlands, affecting mostly young adults vaccinated against mumps. In this retrospective study, we estimated attack rates for symptomatic and asymptomatic mumps virus infection based on mumps-specific immunoglobulin (Ig)G concentrations in paired blood samples obtained before and after the mumps outbreaks, collected in 2 university cities. We aimed to identify a serological correlate of immune protection and risk factors for mumps virus infection.
methodsMumps-specific IgG levels were measured by Luminex technology in paired pre- and post-outbreak samples from students from Leiden (n = 135) and Utrecht (n = 619). Persons with a 4-fold increase in mumps IgG concentrations or mumps IgG concentrations >1500 RU/mL were assumed to have had a mumps virus infection.
resultsAttack rates for symptomatic and asymptomatic mumps virus infection were 2.0% and 3.8%, respectively. Pre-outbreak mumps-specific IgG concentrations were lower among cases than among noncases (P = .005) despite vaccination history, but no serological cutoff for immune protection could be established. Mumps among housemates was significantly associated with serological evidence for mumps virus infection (odds ratio, 7.25 [95% confidence interval, 3.20-16.40]; P < .001).
conclusionsSymptomatic and asymptomatic mumps virus infections in vaccinated persons can be identified by retrospective assessment of mumps-specific IgG antibodies in blood samples.
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