Evidence map›Paper›PMID 25734118›Full record

ArticleOpen forum infectious diseases2014

Ceftaroline in Combination With Trimethoprim-Sulfamethoxazole for Salvage Therapy of Methicillin-Resistant Staphylococcus aureus Bacteremia and Endocarditis.

Valeria Fabre, Marcela Ferrada, Whitney R Buckel, Edina Avdic, Sara E Cosgrove

Erratum issued Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02660346 (A Multi-center Prospective Randomized Open Label Study of Utilizing Interleukin 10), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02660346 phase4completednot on this mapstarted 2015, after this paper: background citation

A Multi-center Prospective Randomized Open Label Study of Utilizing Interleukin 10 (IL-10) Levels as a Guide for Antibiotic Selection for Methicillin Resistant Staphylococcus Aureus Bacteremia

TypeinterventionalSponsorSharp HealthCareRan2015 to 2018Enrolled40ConditionsBacteremiaArmsDaptomycin, Vancomycin, Ceftaroline
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Review
  3. Biofilm Producing Methicillin-ResistantPathogens (Basel, Switzerland) · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Considerations for Clinical Trials of Staphylococcus aureus Bloodstream Infection in Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019
    Article
  10. Observational
  11. Ceftaroline for Severe Methicillin-ResistantOpen forum infectious diseases · 2017
    Review
  12. Infective endocarditis.Nature reviews. Disease primers · 2016
    Review
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Valeria FabreDivision of Infectious Diseases , Johns Hopkins University School of Medicine , Baltimore, Maryland.
Marcela FerradaDivision of Infectious Diseases , Johns Hopkins University School of Medicine , Baltimore, Maryland ; Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland.
Whitney R BuckelDepartment of Pharmacy , Intermountain Medical Center , Murray, Utah.
Edina AvdicDepartment of Pharmacy , Johns Hopkins Hospital , Baltimore, Maryland.
Sara E CosgroveDivision of Infectious Diseases , Johns Hopkins University School of Medicine , Baltimore, Maryland.
Johns Hopkins Medicine · USIntermountain Medical Center · USJohns Hopkins Hospital · USNational Institutes of Health Clinical Center · US

Funding

RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
NIAID NIH HHS T32 AI007291
6 · The paper itself

Abstract

No clinical trials have investigated the use of ceftaroline fosamil for salvage therapy of methicillin-resistant Staphylococcus aureus bacteremia and endocarditis. We report data on 29 patients who received ceftaroline ± another antimicrobial for this indication. Ninety percent of patients had microbiologic cure and 31% had treatment success with a median follow-up of 6 months.

Indexed as

bacteremiaceftaroline fosamilMRSAsalvage

Identifiers

PMID25734118
PMCPMC4281789
OpenAlexW2072030577

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.