ArticleOpen forum infectious diseases2014
Bacteremia with Aerococcus sanguinicola: Case Series with Characterization of Virulence Properties.
Article in Open forum infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Nationwide Observational Case-Control Study of Risk Factors for Aerococcus Bloodstream Infections, Sweden.Emerging infectious diseases · 2025Observational
- Herbal formula alleviates heat stress by improving physiological and biochemical attributes and modulating the rumen microbiome in dairy cows.Frontiers in veterinary science · 2025Article
- Effects of fecal microbiota transplantation on metabolic health of DBA mice.Frontiers in microbiology · 2024Article
- Emerging pathogensFuture microbiology · 2024Article
- Gut microbiota-associated taurine metabolism dysregulation in a mouse model of Parkinson's disease.mSphere · 2023Article
- Fatal infective endocarditis caused byIDCases · 2023Article
- A Case Report of Aerococcus urinae Urinary Tract Infection in an Elderly Male with Multimorbidity.Cureus · 2022Article
- Clinical and microbiological features of Actinotignum bacteremia: a retrospective observational study of 57 cases.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- Article
- A population-based study of aerococcal bacteraemia in the MALDI-TOF MS-era.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Clinical and microbiological features of infective endocarditis caused by aerococci.Infection · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince Aerococcus sanguinicola was designated as a species in 2001, only a few cases of bacteremia have been reported. The aim with this study was to describe the clinical presentation of A sanguinicola bacteremia and to determine the antibiotic susceptibility and the capacity of the bacteria to form biofilm and to induce platelet aggregation.
methodsIsolates of A sanguinicola from blood cultures were retrospectively identified from 2 clinical microbiology laboratories for 2006 to 2012. Species identity was confirmed through sequencing of the 16S rRNA gene. The medical charts of patients were reviewed. The minimum inhibitory concentration (MIC) for relevant antibiotics was determined. Biofilm formation was measured as the amount of crystal violet absorbed. Platelet aggregation was determined by aggregometry.
resultsEleven cases of A sanguinicola bacteremia were identified. All patients were male and the median age was 82 years (range 67-93). Nine patients fulfilled criteria for severe sepsis, and 2 patients died at hospital. Two patients were diagnosed with infective endocarditis. Most patients had underlying urinary tract diseases or an indwelling urinary tract catheter. Five patients suffered from dementia. None of the patients was treated with immunosuppressive medications. The MIC values of the isolates were in line with previous reports, with low MICs for penicillin, cefotaxime, and vancomycin. All 11 isolates produced biofilms but not all could induce platelet aggregation.
conclusionsA sanguinicola can cause severe infections in elderly men with urinary tract abnormalities and the bacteria possess potential virulence mechanisms.
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