ArticleOpen forum infectious diseases2014
Heparin-binding protein: a diagnostic biomarker of urinary tract infection in adults.
Article in Open forum infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The diagnostic utility of heparin-binding protein among patients with bacterial infections: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial.BMJ (Clinical research ed.) · 2017Trial
- Diagnostic utility of the urine neutrophil CD64 ratio for patients with urinary tract infections.Frontiers in medicine · 2026Article
- Biomarkers innovation in urinary tract infections: Insights into pathophysiology, antibiotic resistance, and clinical applications.World journal of nephrology · 2025Review
- Heparin Binding Protein in Sepsis-A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker.Biomedicines · 2025Review
- The value of heparin-binding protein in bronchoalveolar lavage fluid in acute respiratory distress syndrome.Frontiers in medicine · 2025Article
- Heparin-binding Protein as a Diagnostic and Prognostic Marker of Infections: A Systematic Review and Meta-analysis.Mediterranean journal of hematology and infectious diseases · 2025Review
- The diagnostic and prognostic value of heparin-binding protein in cerebrospinal fluid for patients with intracranial infections.European journal of medical research · 2024Article
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Article
- Comprehensive insights into UTIs: from pathophysiology to precision diagnosis and management.Frontiers in cellular and infection microbiology · 2024Review
- Heparin Binding Protein in Early Differential Diagnosis of Bacterial Meningitis.Indian journal of clinical biochemistry : IJCB · 2024Article
- Diagnostic value of plasma heparin-binding protein and the heparin-binding protein-to-albumin ratio in patients with community-acquired Pneumonia: a retrospective study.BMC infectious diseases · 2023Article
- What is the Diagnostic Accuracy of Novel Urine Biomarkers for Urinary Tract Infection?Biomarker insights · 2023Review
- Heparin-Binding Protein in Bronchoalveolar Lavage Fluid as a Biomarker for Discriminating Severe Bacterial and Viral Pneumonia in Critically Ill Children.Mediators of inflammation · 2023Article
- A diagnostic test: combined detection of heparin-binding protein, procalcitonin, and C-reactive protein to improve the diagnostic accuracy of bacterial respiratory tract infections.Journal of thoracic disease · 2022Article
- Heparin-binding protein-enhanced quick SOFA score improves mortality prediction in sepsis patients.Frontiers in medicine · 2022Article
- Serum Interleukin-6 and Interleukin-8 are Sensitive Markers for Early Detection of Pyelonephritis and Its Prevention to Progression to Chronic Kidney Disease.International journal of preventive medicine · 2021Article
- Biomarkers that differentiate false positive urinalyses from true urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2020Article
- Biomarkers in urinary tract infections - which ones are suitable for diagnostics and follow-up?GMS infectious diseases · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infections (UTIs) are associated with significant morbidity and high frequency of antibiotic prescription. Diagnosing UTI is often difficult, particularly in the critically ill patient and in patients with unspecific and mild symptoms. The standard rapid tests have limited value, and there is a need for more reliable diagnostic tools. Heparin-binding protein (HBP) is released from neutrophils and has previously been studied as a diagnostic and predictive biomarker in different bacterial infections.
methodsThis prospective survey enrolled adult patients at 2 primary care units and 2 hospital emergency departments, to investigate in urine HBP as a biomarker of UTI. In addition, urine levels of interleukin-6, white blood cells, and nitrite were analyzed and compared with HBP. Based on symptoms of UTI and microbiological findings, patients were classified into different groups, UTI (cystitis and pyelonephritis) and no UTI.
resultsThree hundred ninety patients were evaluated. The prevalence of UTI in the study group was 45.4%. The sensitivity and specificity for HBP in urine as a marker for UTI were 89.2% and 89.8%, respectively. The positive and negative predictive values were 90.2% and 88.8%, respectively. Heparin-binding protein was the best diagnostic marker for UTI, with an area-under-curve value of 0.94 (95% confidence interval, 0.93-0.96). Heparin-binding protein was significantly better in distinguishing cystitis from pyelonephritis, compared with the other markers.
conclusionsAn elevated level of HBP in the urine is associated with UTI and may be a useful diagnostic marker in adult patients with a suspected UTI.
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